Document Detail

Left ventricular function and beta-blockers: does intrinsic sympathomimetic activity have any influence during chronic therapy?
MedLine Citation:
PMID:  2908709     Owner:  NLM     Status:  MEDLINE    
A study comparing the chronic effects of propranolol (n = 21) and pindolol (n = 19) on male patients with stable angina pectoris was performed. Left ventricular function was assessed by serial radionuclide ventriculography. Radionuclide ventriculography was performed at rest and during cold pressor test. Both drugs improved symptoms of angina pectoris by at least one division of the New York Heart Association classification. Cold pressor testing caused increases in heart rate and blood pressure in both groups throughout the study. At rest, pretreatment ejection fraction was similar in both groups. During propranolol treatment this rose sequentially from 49% to 55% at 26 weeks. No change in the resting ejection fraction occurred in those taking pindolol. The difference in response between the groups reached significance at 26 weeks. In those with subnormal left ventricular ejection fraction (less than 50%), resting ejection fraction improved significantly throughout treatment with propranolol rising from a basal value of 39% to 51% at 26 weeks. In comparison, pindolol caused no significant change. There is no apparent advantage to intrinsic sympathomimetic activity in terms of preservation or improvement of left ventricular performance in patients with stable angina pectoris prescribed beta-blockers for extended periods of time.
R J Northcote; M B Cooke; D Ballantyne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  2     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1991-04-23     Completed Date:  1991-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  549-60     Citation Subset:  IM    
Department of Medical Cardiology, Victoria Infirmary, Glasgow, Scotland.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Middle Aged
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Sympathomimetics

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