Document Detail

Left ventricular flow from apex to base during systole and isovolumic relaxation in a patient with hypertrophic cardiomyopathy and midventricular obstruction.
MedLine Citation:
PMID:  1782938     Owner:  NLM     Status:  MEDLINE    
The occurrence of a left ventricular anterograde flow velocity (maximal: 3.9 m.s-1) is demonstrated in a 32-year-old patient with hypertrophic cardiomyopathy and midventricular obstruction, beginning at early systole and persisting throughout the isovolumic relaxation. Cardiac catheterization with simultaneous dual high fidelity pressure measurements in the apical and basal chambers confirmed the presence of the Doppler maximal instantaneous pressure gradient of 60 mmHg. Contrast left ventricular angiography excluded apical dyskinesia. In the two intracavity compartments, isovolumic relaxation time and the time constant of pressure decay (tau) were abnormal whereby tau was more delayed in the apical than in the basal portion. The presence of an apical high pressure zone during systole with impeded and delayed emptying through the midventricular obstacle and the late onset and prolongation of relaxation are thought to be the cause of the intraventricular flow from apex to base lasting from early systole throughout isovolumic relaxation.
G Sütsch; R Jenni; H P Krayenbühl
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  12     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1132-9     Citation Subset:  IM    
Department of Internal Medicine, Medical Policlinic, Cardiology, University Hospital Zürich, Switzerland.
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MeSH Terms
Blood Flow Velocity
Cardiomyopathy, Hypertrophic / complications,  physiopathology*,  ultrasonography
Echocardiography, Doppler
Heart Catheterization
Heart Ventricles / physiopathology,  ultrasonography
Myocardial Contraction / physiology*
Regional Blood Flow
Systole / physiology
Ventricular Function, Left / physiology*
Ventricular Outflow Obstruction / complications,  physiopathology*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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