Document Detail

Left ventricular filling pattern in hypertensive patients after reversal of myocardial hypertrophy.
MedLine Citation:
PMID:  2960623     Owner:  NLM     Status:  MEDLINE    
After treatment with alpha-methyldopa a regression of left ventricular hypertrophy, due to hypertension, has been reported in spontaneously hypertensive rats. The reduction of left ventricular mass has been associated with an increase in hydroxyproline concentration, suggesting secondary functional changes. On this basis, 12 patients with essential hypertension and echocardiographic evidence of left ventricular hypertrophy have been studied before and after a 6-month alpha-methyldopa treatment. Ten normal subjects were used as a control group. Curves of changes in left ventricular diameter and velocity curves were obtained by digitation of the M-mode endocardial echoes and the diastolic patterns were studied. Before treatment all patients, as compared to normal subjects, showed: (a) prolongation of the isovolumetric relaxation time index, with increased diameter changes; (b) reduction of diameter changes and peak velocity during the rapid filling; and (c) marked compensatory increase of diameter changes and peak velocity of the filling due to atrial systole. Left ventricular hypertrophy was reduced in 5 patients (first group) after treatment. This group showed: (a) normalization of the isovolumetric relaxation time index; (b) slight increase of diameter changes during rapid filling; (c) increased peak velocity of the rapid filling; and (d) reduction of diameter changes and peak velocity during atrial systole. No changes of functional data were observed in the other 7 patients (second group) in whom left ventricular hypertrophy was unchanged after treatment. It is shown how the reduction of left ventricular hypertrophy, per se, could induce such an improvement of diastolic function, despite the biochemical changes probably caused by administration of alpha-methyldopa.
L Agati; F Fedele; M Penco; S Sciomer; A Dagianti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  17     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  IM    
1 Cattedra Malattie Apparato Cardiovascolare, Università La Sapienza, Rome, Italy.
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MeSH Terms
Blood Pressure / drug effects*
Cardiac Volume / drug effects*
Cardiomegaly / drug therapy*
Hypertension / drug therapy*
Methyldopa / therapeutic use*
Middle Aged
Myocardial Contraction / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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