| Left ventricular filling pattern in hypertensive patients after reversal of myocardial hypertrophy. | |
| | |
MedLine Citation:
|
PMID: 2960623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
After treatment with alpha-methyldopa a regression of left ventricular hypertrophy, due to hypertension, has been reported in spontaneously hypertensive rats. The reduction of left ventricular mass has been associated with an increase in hydroxyproline concentration, suggesting secondary functional changes. On this basis, 12 patients with essential hypertension and echocardiographic evidence of left ventricular hypertrophy have been studied before and after a 6-month alpha-methyldopa treatment. Ten normal subjects were used as a control group. Curves of changes in left ventricular diameter and velocity curves were obtained by digitation of the M-mode endocardial echoes and the diastolic patterns were studied. Before treatment all patients, as compared to normal subjects, showed: (a) prolongation of the isovolumetric relaxation time index, with increased diameter changes; (b) reduction of diameter changes and peak velocity during the rapid filling; and (c) marked compensatory increase of diameter changes and peak velocity of the filling due to atrial systole. Left ventricular hypertrophy was reduced in 5 patients (first group) after treatment. This group showed: (a) normalization of the isovolumetric relaxation time index; (b) slight increase of diameter changes during rapid filling; (c) increased peak velocity of the rapid filling; and (d) reduction of diameter changes and peak velocity during atrial systole. No changes of functional data were observed in the other 7 patients (second group) in whom left ventricular hypertrophy was unchanged after treatment. It is shown how the reduction of left ventricular hypertrophy, per se, could induce such an improvement of diastolic function, despite the biochemical changes probably caused by administration of alpha-methyldopa. |
| | |
Authors:
|
L Agati; F Fedele; M Penco; S Sciomer; A Dagianti |
Related Documents
:
|
1022403 - Long-term spontaneous variability of left ventricular end-diastolic pressure. 8281543 - Electrocardiographic findings of heart rate and conduction times in athletic students a... 2756083 - Hostility patterns and cardiovascular reactivity to stress. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 17 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1987 Nov |
Date Detail:
|
Created Date: 1987-12-23 Completed Date: 1987-12-23 Revised Date: 2006-07-12 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 177-85 Citation Subset: IM |
Affiliation:
|
1 Cattedra Malattie Apparato Cardiovascolare, Università La Sapienza, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure
/
drug effects* Cardiac Volume / drug effects* Cardiomegaly / drug therapy* Echocardiography Female Humans Hypertension / drug therapy* Male Methyldopa / therapeutic use* Middle Aged Myocardial Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
|
555-30-6/Methyldopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: RBC aggregometer head as a warning monitor of flow disturbance in extracorporeal systems.
Next Document: Quantitative assessment of pulmonary hypertension in patients with rheumatic heart disease using con...