Document Detail

Left ventricular end-diastolic volume is decreased at maximal exercise in athletes with marked repolarisation abnormalities: a continuous radionuclide monitoring study.
MedLine Citation:
PMID:  15378284     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Although marked repolarisation abnormalities (MRAs) are considered innocuous in trained athletes, their functional significance awaits clarification. The aim of this study was to further evaluate the pathophysiological implications of such MRAs. METHODS: We compared left ventricular (LV) functional response to exhausting exercise in 39 male athletes with (n=22) or without (n=17) MRAs and with no structural cardiac abnormalities, by means of a portable radionuclide monitoring system (Vest, Capintec, Inc., Ramsey, NJ). MRAs were defined by the presence of negative T waves > or =2 mm in three or more rest ECG leads. The Vest data were averaged for 30 s and analysed at baseline and at different heart rate (HR) values (50%, 75%, 85%, 95% and 100% of peak HR), as well as at 2, 5 and 10 min of recovery. RESULTS: There were no significant differences in the effect of exhausting exercise between athletes with and athletes without MRAs. However, there was a significant difference in the trend in end-diastolic volume (EDV) during exercise depending upon the group of athletes considered (p=0.05). EDV differed significantly between the two groups of athletes at peak HR (p=0.031). EDV in athletes with MRAs was lower than that in athletes without MRAs (102%+/-7% vs 107%+/-8%, p=0.034). CONCLUSION: EDV is decreased at peak HR in athletes with MRAs. Such high HR values are infrequently achieved or maintained during sporting activities; therefore, in the absence of structural heart disease, MRAs should not preclude physical training and competitive availability.
Albert Flotats; Ricard Serra-Grima; Valle Camacho; Esther Mena; Xavier Borràs; Montserrat Estorch; Ana Tembl; Jordi Fuertes; Juan Cinca; Ignasi Carrió
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article     Date:  2004-09-16
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  32     ISSN:  1619-7070     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-03     Completed Date:  2005-08-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Department of Nuclear Medicine, Hospital de la Santa Creu i Sant Pau, Sant Antoni M. Claret, 167, 08025, Barcelona, Spain.
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MeSH Terms
Heart Conduction System / physiology*
Heart Rate / physiology
Heart Ventricles / radionuclide imaging*
Monitoring, Ambulatory / instrumentation,  methods
Physical Endurance / physiology*
Physical Fitness / physiology
Sports / physiology*
Stroke Volume / physiology*
Ventricular Function*
Ventricular Function, Left / physiology*

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