Document Detail

Left ventricular ejection fraction and its response to therapy in essential hypertension.
MedLine Citation:
PMID:  7029318     Owner:  NLM     Status:  MEDLINE    
Left ventricular ejection fraction at rest and during treadmill and isometric handgrip exercise were determined in 16 patients with essential hypertension (mean age 47.4 years) before and after therapy. The untreated hypertensive patient showed a linear correlation between mean blood pressure and LVEF (r = 0.62, p less than 0.01). The relation of sitting, resting LVEF with systolic blood pressure was highly significant (r = 0.88, p less than 0.001). Prior to therapy no significant change in LVEF in response to exercise was noted. After therapy with captopril, a normal isotonic exercise response occurred consisting of a highly significant increase in ejection fraction (p less than 0.0025). Subjects receiving propranolol had a fall in LVEF with isometric stress (p less than 0.0025). These data suggest an increased ejection fraction in patients with essential hypertension when all other parameters of the heart are normal and an abnormal response to isotonic exercise which may be reversed with therapy.
M D Blaufox; J P Wexler; R A Sherman; S C Scharf; E H Sonnenblick; J A Strom; H B Lee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nephron     Volume:  28     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1981  
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  IM    
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MeSH Terms
Captopril / therapeutic use
Cardiac Output / drug effects*
Exercise Test
Heart Ventricles / physiopathology
Hypertension / drug therapy*,  physiopathology
Middle Aged
Propranolol / therapeutic use
Renin / secretion
Stroke Volume / drug effects*
Reg. No./Substance:
525-66-6/Propranolol; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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