Document Detail

Left ventricular ejection fraction in obstructive sleep apnea. Effects of long-term treatment with nasal continuous positive airway pressure.
MedLine Citation:
PMID:  1914605     Owner:  NLM     Status:  MEDLINE    
The effects of treatment with nasal continuous positive airway pressure (CPAP) on left ventricular ejection fraction (LVEF) were assessed in 29 patients with obstructive sleep apnea (OSA) in a prospective study using multiple gated equilibrium radionuclide angiocardiography. All patients were evaluated before CPAP treatment was initiated and were reevaluated after one year (mean +/- SE, 415 +/- 6 days), of home treatment with nasal CPAP. The mean LVEF increased from 59 +/- 1 percent to 63 +/- 1 percent (p less than 0.005). The degree of improvement in LVEF was correlated with baseline LVEF (r = 0.54; p less than 0.003), meaning that the lower the baseline value, the greater the increase with treatment. The changes were not different when subgroups of medicated and unmedicated patients were considered separately. These results show that long-term nasal CPAP treatment results in improved left ventricular function in OSA.
J Krieger; D Grucker; E Sforza; J Chambron; D Kurtz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  100     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-11-15     Completed Date:  1991-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  917-21     Citation Subset:  AIM; IM    
Service d'Exploration Fonctionnelle du Système Nerveux, Clinique Neurologique CHU, Strasbourg, France.
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MeSH Terms
Evaluation Studies as Topic
Follow-Up Studies
Gated Blood-Pool Imaging
Middle Aged
Positive-Pressure Respiration*
Prospective Studies
Sleep Apnea Syndromes / physiopathology,  radionuclide imaging,  therapy*
Stroke Volume / physiology*
Time Factors

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