Document Detail


Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation.
MedLine Citation:
PMID:  18204139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine the prevalence of left ventricular (LV) dysfunction in patients with advanced interstitial lung disease (ILD) and the relationship between LV function and factors limiting physical activity. In 2005-2006, 40 patients with end stage ILD were admitted with qualifications for lung transplantation (LT). From this group, 18 patients (7 women, 11 men) were referred for LT (active list), 22 patients (8 women, 14 men), who did not meet the ATS/ERS criteria for LT were excluded from this procedure (waiting list). All patients had echocardiography, spirometry, 6-min walking test (6MW), and gas exchange measurements. The following main echocariographic data that describe the LV function and morphology were taken into account: LVs, LVd, LVPWd, LVPWs, Ao, LA, ESV, EDV, and EF. We noted significant differences in LVPWd (P=0.01), ESV (P=0.01), and EDV (P=0.02), which presented lower values in patients on the active list compared with those on the waiting list. A positive correlation was found between 6MW and LVs (r=0.41), LA (r=0.45), ESV (r=0.62), and EDV (r=0.68). Correlations between spirometric, gas exchange, and left ventricle echocardiographic data were also observed. We conclude that patients on active list for lung transplantation present a decrease in the diameter and volume of the left ventricle. The latter change may influence the functional ability of interstitial lung disease patients.
Authors:
D Jastrzebski; J Nowak; D Ziora; J Wojarski; D Czyzewski; J Kozielski; L Polonski; M Zembala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  58 Suppl 5     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Affiliation:
Department of Lung Diseases and Tuberculosis, Silesian School of Medicine, Zabrze, Poland. darekjdr@poczta.onet.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Lung Diseases, Interstitial / complications*,  physiopathology,  surgery,  ultrasonography
Lung Transplantation*
Male
Middle Aged
Poland / epidemiology
Prevalence
Pulmonary Gas Exchange
Referral and Consultation*
Retrospective Studies
Severity of Illness Index
Spirometry
Stroke Volume
Ventricular Dysfunction, Left / etiology*,  physiopathology,  ultrasonography
Ventricular Pressure
Waiting Lists*
Walking

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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