| Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation. | |
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MedLine Citation:
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PMID: 18204139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the prevalence of left ventricular (LV) dysfunction in patients with advanced interstitial lung disease (ILD) and the relationship between LV function and factors limiting physical activity. In 2005-2006, 40 patients with end stage ILD were admitted with qualifications for lung transplantation (LT). From this group, 18 patients (7 women, 11 men) were referred for LT (active list), 22 patients (8 women, 14 men), who did not meet the ATS/ERS criteria for LT were excluded from this procedure (waiting list). All patients had echocardiography, spirometry, 6-min walking test (6MW), and gas exchange measurements. The following main echocariographic data that describe the LV function and morphology were taken into account: LVs, LVd, LVPWd, LVPWs, Ao, LA, ESV, EDV, and EF. We noted significant differences in LVPWd (P=0.01), ESV (P=0.01), and EDV (P=0.02), which presented lower values in patients on the active list compared with those on the waiting list. A positive correlation was found between 6MW and LVs (r=0.41), LA (r=0.45), ESV (r=0.62), and EDV (r=0.68). Correlations between spirometric, gas exchange, and left ventricle echocardiographic data were also observed. We conclude that patients on active list for lung transplantation present a decrease in the diameter and volume of the left ventricle. The latter change may influence the functional ability of interstitial lung disease patients. |
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Authors:
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D Jastrzebski; J Nowak; D Ziora; J Wojarski; D Czyzewski; J Kozielski; L Polonski; M Zembala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 58 Suppl 5 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 299-305 Citation Subset: IM |
Affiliation:
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Department of Lung Diseases and Tuberculosis, Silesian School of Medicine, Zabrze, Poland. darekjdr@poczta.onet.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Lung Diseases, Interstitial / complications*, physiopathology, surgery, ultrasonography Lung Transplantation* Male Middle Aged Poland / epidemiology Prevalence Pulmonary Gas Exchange Referral and Consultation* Retrospective Studies Severity of Illness Index Spirometry Stroke Volume Ventricular Dysfunction, Left / etiology*, physiopathology, ultrasonography Ventricular Pressure Waiting Lists* Walking |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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