|Left ventricular dysfunction and dilated cardiomyopathy in infants and children with wolff-Parkinson-white syndrome in the absence of tachyarrhythmias.|
|Jump to Full Text|
|PMID: 23323117 Owner: NLM Status: PubMed-not-MEDLINE|
|Left ventricular (LV) dysfunction and dilated cardiomyopathy (DCM) are rarely attributable to sustained or incessant tachyarrhythmias in infants and children with Wolff-Parkinson-White (WPW) syndrome. However, several recent reports suggested that significant LV dysfunction may develop in WPW syndrome in the absence of tachyarrhythmias. It is assumed that an asynchronous ventricular activation over the accessory pathway, especially right-sided, induces septal wall motion abnormalities, ventricular remodeling and ventricular dysfunction. The prognosis of DCM associated with asymptomatic WPW is excellent. Loss of ventricular pre-excitation results in mechanical resynchronization and reverse remodeling where LV function recovers completely. The reversible nature of LV dysfunction after loss of ventricular pre-excitation supports the causal relationship between LV dysfunction and ventricular pre-excitation. This review summarizes recent clinical and electrophysiological evidence for development of LV dysfunction or DCM in asymptomatic WPW syndrome, and discusses the underlying pathophysiological mechanism.|
Related Documents :
|6477387 - The relationship between myocardial oxygen consumption and total work obtained by a new...
18609057 - Aerobic interval training improves vo2 peak in coronary artery disease patients; no add...
6723727 - How seals avoid myocardial infarction when they should have got it.
10384187 - Myocardial substrate uptake and oxidation during and after routine cardiac surgery.
2252767 - Hemopump ventricular support for patients undergoing high risk coronary angioplasty.
6584207 - Aclarubicin-associated qtc prolongation and ventricular fibrillation.
|Type: Journal Article Date: 2012-12-31|
|Title: Korean circulation journal Volume: 42 ISSN: 1738-5520 ISO Abbreviation: Korean Circ J Publication Date: 2012 Dec|
|Created Date: 2013-01-16 Completed Date: 2013-01-17 Revised Date: 2013-05-30|
Medline Journal Info:
|Nlm Unique ID: 101247141 Medline TA: Korean Circ J Country: Korea (South)|
|Languages: eng Pagination: 803-8 Citation Subset: -|
|Division of Pediatric Cardiology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.|
|APA/MLA Format Download EndNote Download BibTex|
Journal ID (nlm-ta): Korean Circ J
Journal ID (iso-abbrev): Korean Circ J
Journal ID (publisher-id): KCJ
Publisher: The Korean Society of Cardiology
Copyright © 2012 The Korean Society of Cardiology
Print publication date: Month: 12 Year: 2012
Electronic publication date: Day: 31 Month: 12 Year: 2012
Volume: 42 Issue: 12
First Page: 803 Last Page: 808
PubMed Id: 23323117
|Left Ventricular Dysfunction and Dilated Cardiomyopathy in Infants and Children with Wolff-Parkinson-White Syndrome in the Absence of Tachyarrhythmias|
|JaeKon Ko, MDA1|
|Division of Pediatric Cardiology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
|Correspondence: Correspondence: JaeKon Ko, MD, Division of Pediatric Cardiology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: 82-2-3010-3375, Fax: 82-2-473-3725, email@example.com
Wolff-Parkinson-White (WPW) syndrome is characterized by ventricular pre-excitation that ventricles are electrically and mechanically pre-excited through an accessory pathway, which connects atria and ventricles. Supraventricular tachycardia is frequently associated with symptomatic WPW syndrome in clinical practice. A rare cause of morbidity in infants and children with WPW syndrome is left ventricular (LV) dysfunction or dilated cardiomyopathy (DCM), which may attribute to the recurrent or incessant tachycardia.1), 2) Recently however, several small case series and case reports suggested a possible association between accessory pathways and ventricular dysfunction in the absence of sustained tachyarrhythmias.3-11) The eccentric premature ventricular activation via an accessory pathway results in an asynchronous spread of ventricular depolarization and this asynchronous ventricular activation may provoke ventricular dysfunction.12) The occurrence of ventricular dysfunction in asymptomatic WPW syndrome may depend on the location of the accessory pathway, and invariably it was reported the electrophysiological features was the right sided accessory pathway, especially in the septal or paraseptal location.7), 10) It is thought that this type of accessory pathway induces abnormal interventricular septal wall motion leading to LV dyssynchrony and subsequently ventricular dysfuction or DCM through LV remodeling. This non-tachycardia type of LV dysfunction with WPW syndrome is characterized by complete recovery of the ventricular function after ablation or spontaneous regression of pre-excitation. It is the purpose of this article to review the clinical and electrophysiologic evidence for this association and to discuss the underlying pathophysiological mechanism.
The prevalence of LV dysfunction associated with WPW syndrome in the absence of tachyarrhythmias is unknown. Age distribution of these patients with pre-excitation related LV dysfunction is wide, ranging from infants to old age. In 1998 Yamanaka et al.3) suggested the association between LV dysfunction and WPW syndrome for the first time in a 67 year old man with type B WPW syndrome, of whom cardiac function improved after catheter ablation. Several years thereafter, in 2004 Emmel et al.4) described the improvement of ventricular function after the disappearance of pre-excitation in 4 children with DCM associated with WPW syndrome, and suggested a causal relationship between ventricular pre-excitation and DCM. Thereafter, only several small case series and case reports have been reported until now and summarized in Table 1. However, the incidence of this association might have been underestimated. Some patients with abnormal wall motion might have undergone an electrophysiological study and catheter ablation before overt ventricular dysfunction developed. It is also possible that some patients have been considered only to have idiopathic DCM coincidentally.
Patients with manifested antegrade accessory pathway conduction have asynchronous ventricular wall motion because of abnormal impulse propagation by premature eccentric ventricular activation over a bypass tact. Systolic and diastolic wall motion abnormalities have been well described in WPW syndrome. It was found in the earlier echocardiographic studies13-16) that the pattern of abnormal ventricular contraction was dependent on the location of the accessory pathway. Left-sided accessory pathways produced premature anterior motion in the posterior LV wall and right-sided accessory pathways showed abnormal interventricular septal motion. Left-sided accessory pathways producing typical anterior motion of the LV posterior wall is visible on M-mode echocardiography in early systole as a small, distinct bump and this unopposed early contraction of the posterior wall results in abnormal anterior motion of the interventricular septum. The right-sided accessory pathway related abnormal interventricular septal motion consists of an early systolic posterior and subsequent midsystolic anterior motion, with a delay in the usual late systolic septal movement. These abnormal septal motions in type B WPW syndrome are similar to those described in patients with left bundle branch block (LBBB). Grines et al.17) observed abnormal interventricular septal motion in patients with LBBB and this abnormal septal motion in LBBB corresponded to periods of asynchrony in contraction, ejection, end systole, and end diastole between the right and left ventricle. They also found that regional ejection fraction of the septum decreased in LBBB compared with that of normal subjects and this loss of septal contribution resulted in a reduction in global ejection fraction in LBBB compared to normal subjects.
In the earlier echocardiographic studies, they observed that abnormal septal motion was normalized after loss of pre-excitation in patients with type B WPW syndrome and suggested that abnormal septal motion is related to the altered sequence of ventricular activation during pre-excitation.14), 15)
Several recent studies suggested that WPW syndrome may lead to regional and global contractile dysfunction resulting from aberrant impulse propagation.5), 9), 10), 12) The right septal and paraseptal accessory pathways have been considered the main location to induce LV dysfunction. Tomaske et al.7) showed in 56% of patients with right septal or posteroseptal accessory pathways, LV ejection fraction decreased and septal-to-posterior wall motion delay increased. They discussed the importance of septal and posteroseptal location of accessory pathways to cause ventricular dysfunction. The extent of the pre-excited ventricular myocardium depends on the relative timing of normal and eccentric ventricular activation. In left free wall pathways, the amount of pre-excited myocardium is rather small because of long conduction time from the sinus node to the atrial pathway insertion leading to almost normal activation of the left ventricle via atrioventricular nodal conduction. In right free wall pathways, LV activation is almost synchronous over the normal conduction pathway, with a precontraction area being limited to the right ventricular free wall. In contrast to right free wall pathways, septal and posteroseptal pathways may induce earlier interventricular activation, subsequently substantial part of septal pre-excitation and delayed activation of LV free wall.
Early septal activation may induce paradoxical or hypokinetic interventricular septal motion, similar to septal motion abnormalities seen in patients with right ventricular pacing or LBBB, and this dyskinetic segment may function like an aneurysm and induce adverse remodeling with progressive dilation. The detrimental effect of chronic right ventricular pacing or LBBB on LV function has been well described. Chronic asynchronous electric activation in the patients with LBBB or right ventricular pacing disturbs the myocardial regional workload and wall stress, which may result in abnormal wall motion, regional myocardial perfusion defects leading to adverse remodeling with asymmetry of wall thickness and progressive LV dilation.17-20) In an animal study,21) the abnormal impulse propagation by ventricular pacing causes considerable disturbances in regional systolic fiber shortening, mechanical work, blood flow, and oxygen consumption - and in early activated regions, the values are low.
An early activation of the basal septum via septal and paraseptal pathways will induce segmental contraction which is unopposed by the activation of the remaining left ventricle. On these early contracting segments, imposed preload will be low, resulting in decreased myocardial work and thinning of the myocardium, which is manifested as extreme systolic bulging of the pre-excited basal septum towards the right ventricle. Fig. 1 shows paradoxical systolic bulging of the basal septum in a 9-year-old girl with right anterior accessory pathway. This early basal septal segmental contraction with bulging and delayed free wall activation may lead to significant dyssynchrony in the LV motion and thereby cause ventricular dysfunction. A study using recent echocardiographic technique22) showed local ejecting shortening was impaired at the pre-excitation site and at similar electrical and mechanical dyssynchrony, WPW syndrome with septal accessory pathways had more extensive hypokinesia than did WPW syndrome with LV free wall accessory pathways. Kwon et al.9) reported that LV systolic function was reduced in all patients with septal pathways, compared to patients with left or right free wall pathways. In their study, compared to patients with normal septal motion, patients with septal dyskinesia had a reduced LV ejection fraction and an increased LV end diastolic dimension. Tomaske et al.7) also suggested that WPW syndrome with right septal or posteroseptal pathways may cause LV dyssynchrony and jeopardize global LV function. They used conventional echocardiographic and recent speckle tracking imaging techniques to see LV dyssynchrony in patients with septal accessory pathways. In these two recent studies, significant LV dyssynchrony disappeared after catheter ablation with subsequent improvement of systolic LV function. These observations support the importance of dyssynchrony in the pathogenesis of LV dysfunction associated with ventricular pre-excitation. Fig. 2 shows a heterogeneous pattern in the radial strain assessment using 2-dimensional speckle tracking echocardiography that changed into a more homogeneous pattern after catheter ablation of the right anterior accessory pathway in a 9-year-old girl with asymptomatic WPW syndrome.
However, It is unknown why not all patients with right sided accessory pathways develop ventricular dysfunction, in the absence of incessant tachyarrhythmias. In 1977, Levovitz et al.16) suggested that the determinants of abnormal septal wall motions are the location, right ventricular lateral freewall or septal and degree of ventricular pre-excitation. They reported that asynchronous movement was observed only in their patients in whom duration of the QRS complex was greater than 130 msec. In the study by Kwon et al.,9) all patients with septal dyskinesia and reduced LV ejection fraction showed longer pre-excited QRS duration than those with normal septal motion. Another recent study suggested that different locations of paraseptal accessory pathways may induce a variable degree of LV dyssynchrony and dysfunction. Tomaske et al.7) reported that their patients with midseptal and anteroseptal pathways demonstrated lower LV ejection fraction and a higher degree of intraventricular LV dyssynchrony compared with those with posteroseptal pathways. The degree of pre-excitation and the degree of dyssynchrony induced by the different location of the accessory pathway may be the additional factor for development of ventricular dysfunction in these patients.
The prognosis of accessory pathway induced LV dysfunction or DCM is excellent. In the reported cases shown in Table 1, cardiac function improved and normalized acutely or within several months after loss of pre-excitation, either spontaneously or by catheter ablation or appropriate medical therapy. These findings suggest that recovery of ventricular function through LV reverse remodeling occurs after loss of ventricular pre-excitation. In infants and small children, catheter ablation is chosen as a last alternative therapy due to its higher risk of complications and uncertain long-term effect of ablation scars on young myocardium.23), 24) Cadrin-Tourigny et al.6) reported severe LV dysfunction in two young infants with asymptomatic WPW syndrome and in both infants, successful pharmacologic suppression of posteroseptal accessory pathway conduction with amiodarone resulted in dramatic improvement in LV function. It further supports the pathogenic association of accessory pathway with LV dysfunction or DCM. Therefore, accessory pathway associated ventricular dysfunction should be suspected in all patients presenting with DCM and ventricular pre-excitation, especially with right sided accessory pathways, when tachyarrhythmias induced ventricular dysfunction is ruled out. However, many asymptomatic patients with WPW and septal and paraseptal accessory pathways may have abnormal ventricular wall motion without overt ventricular dysfunction or DCM and the catheter ablation of accessory pathways in these patients is still controversial. It seems reasonable that catheter ablation should be reserved for those patients in whom progression of adverse LV remodeling and deteriorating cardiac function are demonstrated in the conventional and recently developed techniques of echocardiography during follow-up.
The causal relationship between LV dysfunction or DCM and WPW syndrome in the absence of tachyarrhythmias is recently recognized. Right-sided accessory pathways may induce LV dyssynchrony, leading to adverse remodeling and ventricular dysfunction. The prognosis of these patients is excellent. Loss of ventricular pre-excitation spontaneously or by catheter ablation results in mechanical resynchronization, reverse remodeling and LV function recovers completely.
The authors have no financial conflicts of interest.
|1.||Fenelon G,Wijns W,Andries E,Brugada P. Tachycardiomyopathy: mechanisms and clinical implicationsPacing Clin ElectrophysiolYear: 199619951068848384|
|2.||Horenstein MS,Saarel E,Dick M,Karpawich PP. Reversible symptomatic dilated cardiomyopathy in older children and young adolescents due to primary non-sinus supraventricular tachyarrhythmiasPediatr CardiolYear: 20032427427912545317|
|3.||Yamanaka S,Shirayama T,Inoue K,Kawata K,Yagi T,Azuma A,et al. Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarctionJpn Circ JYear: 1998628608629856605|
|4.||Emmel M,Balaji S,Sreeram N. Ventricular preexcitation associated with dilated cardiomyopathy: a causal relationship?Cardiol YoungYear: 20041459459915679994|
|5.||Fazio G,Mongiovi' M,Sutera L,Novo G,Novo S,Pipitone S. Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathyInt J CardiolYear: 2008123e31e3417292982|
|6.||Cadrin-Tourigny J,Fournier A,Andelfinger G,Khairy P. Severe left ventricular dysfunction in infants with ventricular preexcitationHeart RhythmYear: 200851320132218774110|
|7.||Tomaske M,Janousek J,Rázek V,et al. Adverse effects of Wolff-Parkinson-White syndrome with right septal or posteroseptal accessory pathways on cardiac functionEuropaceYear: 20081018118918256123|
|8.||Iwasaku T,Hirooka K,Taniguchi T,et al. Successful catheter ablation to accessory atrioventricular pathway as cardiac resynchronization therapy in a patient with dilated cardiomyopathyEuropaceYear: 20091112112319028709|
|9.||Kwon BS,Bae EJ,Kim GB,Noh CI,Choi JY,Yun YS. Septal dyskinesia and global left ventricular dysfunction in pediatric Wolff-Parkinson-White syndrome with septal accessory pathwayJ Cardiovasc ElectrophysiolYear: 20102129029519804548|
|10.||Udink ten Cate FE,Kruessell MA,Wagner K,et al. Dilated cardiomyopathy in children with ventricular preexcitation: the location of the accessory pathway is predictive of this associationJ ElectrocardiolYear: 20104314615419879594|
|11.||Martí-Almor J,Bazan V,Morales M,Guerra JC. [Heart failure in a patient with Wolff-Parkinson-White syndrome]Rev Esp CardiolYear: 2011641217121821664748|
|12.||Udink Ten Cate FE,Wiesner N,Trieschmann U,Khalil M,Sreeram N. Dyssynchronous ventricular activation in asymptomatic wolff-Parkinson-white syndrome: a risk factor for development of dilated cardiomyopathyIndian Pacing Electrophysiol JYear: 20101024825620552060|
|13.||DeMaria AN,Vera Z,Neumann A,Mason DT. Alterations in ventricular contraction pattern in the Wolff-Parkinson-White syndrome. Detection by echocardiographyCirculationYear: 1976532492571245032|
|14.||Francis GS,Theroux P,O'Rourke RA,Hagan AD,Johnson AD. An echocardiographic study of interventricular septal motion in the Wolff-Parkinson-White syndromeCirculationYear: 197654174178181165|
|15.||Ticzon AR,Damato AN,Caracta AR,Russo G,Foster JR,Lau SH. Interventricular septal motion during preexcitation and normal conduction in Wolff-Parkinson-White syndrome: echocardiographic and electrophysiologic correlationAm J CardiolYear: 1976378408471266749|
|16.||Lebovitz JA,Mandel WJ,Laks MM,Kraus R,Weinstein S. Relationship between the electrical (electrocardiographic) and mechanical (echocardiographic) events in Wolff-Parkinson-White syndromeChestYear: 197771463469852320|
|17.||Grines CL,Bashore TM,Boudoulas H,Olson S,Shafer P,Wooley CF. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchronyCirculationYear: 1989798458532924415|
|18.||Prinzen FW,Cheriex EC,Delhaas T,et al. Asymmetric thickness of the left ventricular wall resulting from asynchronous electric activation: a study in dogs with ventricular pacing and in patients with left bundle branch blockAm Heart JYear: 1995130104510537484735|
|19.||Tantengco MV,Thomas RL,Karpawich PP. Left ventricular dysfunction after long-term right ventricular apical pacing in the youngJ Am Coll CardiolYear: 2001372093210011419893|
|20.||Thambo JB,Bordachar P,Garrigue S,et al. Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacingCirculationYear: 20041103766377215583083|
|21.||Prinzen FW,Peschar M. Relation between the pacing induced sequence of activation and left ventricular pump function in animalsPacing Clin ElectrophysiolYear: 2002254 Pt 148449811991375|
|22.||De Boeck BW,Teske AJ,Leenders GE,et al. Detection and quantification by deformation imaging of the functional impact of septal compared to free wall preexcitation in the Wolff-Parkinson-White syndromeAm J CardiolYear: 201010653954620691313|
|23.||Kugler JD,Danford DA,Houston KA,Felix G. Pediatric Radiofrequency Ablation Registry of the Pediatric Radiofrequency Ablation Registry of the Pediatric Electrophysiology SocietyPediatric radiofrequency catheter ablation registry success, fluoroscopy time, and complication rate for supraventricular tachycardia: comparison of early and recent erasJ Cardiovasc ElectrophysiolYear: 20021333634112033349|
|24.||Saul JP,Hulse JE,Papagiannis J,Van Praagh R,Walsh EP. Late enlargement of radiofrequency lesions in infant lambs. Implications for ablation procedures in small childrenCirculationYear: 1994904924998026036|
Keywords: Wolff-Parkinson-White syndrome, Ventricular dysfunction, left, Cardiomyopathy, dilated.
Previous Document: Primary Mucinous Cystadenocarcinoma of the Breast: Cytologic Finding and Expression of MUC5 Are Diff...
Next Document: Auscultatory measured normative blood pressure of korean adolescents: using the korean national heal...