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Left ventricular dysfunction is associated with cerebral grey matter injury: An in-vivo brain MRI segmentation study.
MedLine Citation:
PMID:  22874822     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Patients with heart failure often experience cognitive deficits. The relationship between systolic function and cerebral gray matter injury is unclear. METHODS: An automated program SIENAX (v2.2) was used to extract brain volume and for segmentation of grey and white matter in subjects with low left ventricular ejection fraction (<50%) and normal ejection fraction (≥50%). T1-weighted spin-echo axial sequences were used for analysis. RESULTS: 14 cases with low left ventricular ejection fraction and 14 age-matched controls were evaluated. A modest correlation between grey matter volume and low left ventricular ejection fraction was demonstrated (r=0.51, p=0.06), not seen with white matter volumes. The mean grey matter volume was 507.4±166.3ml in the low left ventricular ejection fraction group and 541.3±167.2ml in the control group (p=0.57). CONCLUSION: Low left ventricular ejection fraction may lead to cerebral grey matter injury. Larger studies including multi-modal MRI and neuropsychological assessments are warranted to explore potential mechanisms.
Authors:
Pratik Bhattacharya; Fen Bao; Megha Shah; Gautam Ramesh; Ramesh Madhavan; Omar Khan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-5
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Comprehensive Stroke Program, Department of Neurology, Wayne State University School of Medicine, Detroit, United States.
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