| Left ventricular diastolic functions in juvenile rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 10865017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac involvement as pericarditis, myocarditis, and endocarditis is common in juvenile rheumatoid arthritis (JRA). Though there are many reports concerning systolic and diastolic functions of adults with rheumatoid arthritis, there are no studies on children with JRA. Thirty patients with JRA without any cardiac symptoms and 30 sex- and age-matched controls were included in the study. M-mode and pulsed-wave Doppler echocardiography were performed on each participant to assess the systolic and diastolic functions of the left ventricle. Left ventricular end-systolic diameter and volume were larger and ejection fraction and fractional shortening were decreased in the JRA group. Among the diastolic parameters, increased late flow velocity, decreased early flow velocity, and prolonged isovolumic relaxation time reflected an abnormal relaxation form of diastolic dysfunction. Mortality rate is increased in adults with rheumatoid arthritis, and ischemic heart disease is the leading cause of cardiovascular mortality. The abnormal relaxation form of diastolic dysfunction found in children with JRA is seen in ischemic heart disease. These children can therefore be candidates for ischemic heart disease in the future even though they are fully asymptomatic at present. In conclusion, children with JRA should be assessed for systolic and diastolic functions with serial echocardiography. In this way it may be possible to reduce the mortality and morbidity of the disease from cardiac causes. |
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Authors:
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D Oguz; B Ocal; U Ertan; H Narin; S Karademir; F Senocak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric cardiology Volume: 21 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2000 Jul-Aug |
Date Detail:
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Created Date: 2000-08-23 Completed Date: 2000-08-23 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 374-7 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arthritis, Juvenile Rheumatoid / physiopathology* Child Child, Preschool Diastole / physiology* Echocardiography, Doppler, Pulsed Female Humans Male Systole / physiology Ventricular Function, Left* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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