Document Detail

Left ventricular diastolic function and responses to adrenergic stimuli in borderline arterial hypertension.
MedLine Citation:
PMID:  1315820     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To detect the existence of a possible relationship between arterial hypertension and adrenergic reactivity to pressure stimuli, and changes in left ventricular diastolic function (LVDF). PATIENTS: Fifty-nine young subjects with borderline arterial hypertension and ten sex- and age-matched controls were investigated. After three medical examinations, the subjects were divided into hypertensive and borderline groups on the basis of the blood pressure reading at visit 3. A complete echocardiographic study was performed in 25 of the 59 subjects. DESIGN: Blood pressure was measured in baseline conditions and during pressure stimuli (mental stress, handgrip and cold pressor tests). LVDF was evaluated primarily by means of filling velocities during diastolic phases taken from the left ventricular volume curve (obtained from a complete echocardiographic study). RESULTS: No significant changes in blood pressure responses were observed for the borderline or hypertensive groups during the adrenergic test. The echocardiographic indices of diastolic function were statistically different for the two groups when compared with the control group. The LVDF parameters correlated significantly with systolic blood pressure and diastolic blood pressure measured at the time of the echocardiogram, but not with blood pressure measured occasionally. CONCLUSIONS: Blood pressure increases similarly during adrenergic stimuli in both the hypertensive and borderline groups. The correlation between systolic blood pressure, diastolic blood pressure and LVDF parameters may indicate a very early onset of reduced compliance of the left ventricle, even in a preclinical phase of hypertension.
G Covi; I Sheiban; G P Gelmini; C Zenorini; A Mileto; A Girelli; A Lechi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  10     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-11     Completed Date:  1992-06-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Clinica Medica, University of Verona, Italy.
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MeSH Terms
Blood Pressure Determination / methods
Cold Temperature / diagnostic use
Diastole / physiology*
Hypertension / physiopathology*,  ultrasonography
Physical Exertion / physiology
Receptors, Adrenergic / physiology*
Stress, Psychological / physiopathology
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Receptors, Adrenergic

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