| Left ventricular diastolic function in hypertensive patients. | |
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MedLine Citation:
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PMID: 3791619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular filling rate has been shown to be depressed in hypertensive patients before any alteration in indexes of systolic function. The mechanism(s) underlying this abnormality is not known. However, several factors were found to influence left ventricular filling rate. The relative importance of these factors is emerging from studies performed at various centers. Of these, the adrenergic drive, coronary blood flow, heart rate, afterload, and calcium reuptake mechanisms seem to be important. Physiologically, the index of left ventricular filling should therefore be normalized to allow comparison between different individuals. Using a normalized index (filling rate/emptying rate), we found in a small group (n = 13) of hypertensive patients that the increase in total peripheral resistance during head-up tilt was blunted in those with reduced left ventricular filling, suggesting that this abnormality in diastolic function accompanying hypertension plays a role in cardiovascular regulation by altering sensitivity of cardiopulmonary reflexes. |
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Authors:
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F M Fouad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 75 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-02-05 Completed Date: 1987-02-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: I48-55 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cardiovascular System / physiopathology Coronary Circulation Diastole* Heart / physiopathology* Heart Conduction System / physiopathology Humans Hypertension / metabolism, physiopathology* Kinetics Myocardial Contraction* Myocardium / metabolism Reflex / physiology Sympathetic Nervous System / physiopathology |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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