Document Detail


Left ventricular diastolic function in workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement.
MedLine Citation:
PMID:  22820423     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the study was to evaluate left ventricular diastolic function in workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement. The studies included 115 workers (92 men and 23 women) occupationally exposed to mercury vapour without clinical presentation of cardiac involvement (mean age: 47.83±8.29). Blood samples were taken to determine blood lipid profile, urine was collected to estimate mercury concentration (Hg-U) and echocardiographic examination was performed to evaluate diastolic function of the left ventricle. In the entire group of workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement, Spearman correlations analysis demonstrated the following significant linear relationships: between body mass index (BMI) and ratio of maximal early diastolic mitral flow velocity/early diastolic mitral annular velocity (E/E`) (r=0.32, p<0.05), between serum HDL concentration and E/E` (r=-0.22, p<0.05), between Hg-U and E/E` (r=0.35, p<0.05), between Hg-U and isovolumetric relaxation time (IVRT`) (r=0.41, p<0.05), between Hg-U and ratio of maximal early diastolic mitral flow velocity/maximal late diastolic mitral flow velocity (E/A) (r=-0.31, p<0.05) and between serum HDL concentration and E/A (r=0.43, p<0,05). In logistic regression analysis it as shown that independent factors of left ventricular diastolic dysfunction risk in the study group included a higher urine mercury concentration, a higher value of BMI and a lower serum HDL concentration (OR(Hg-U)=1.071, OR(BMI)=1.200, OR(HDL)=0.896, p<0.05). Summing up, occupational exposure to mercury vapour may be linked to impaired left ventricular diastolic function in workers without clinical presentation of cardiac involvement.
Authors:
Rafał Poręba; Anna Skoczyńska; Paweł Gać; Barbara Turczyn; Anna Wojakowska
Related Documents :
10980843 - Low molecular weight heparin in acute coronary syndromes.
9456103 - Thromboxane production in human lung during cardiopulmonary bypass: beneficial effect o...
3044793 - Effect of vasodilator therapy on mortality in chronic congestive heart failure.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-18
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  -     ISSN:  1096-0333     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intravenous application of an Anticalin dramatically lowers plasma digoxin levels and reduces its to...
Next Document:  Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activ...