Document Detail

Left ventricular diastolic function in a predialysis patient population.
MedLine Citation:
PMID:  20931508     Owner:  NLM     Status:  In-Process    
BACKGROUND: Diastolic dysfunction is common in chronic kidney disease (CKD) accounting for 40%-66% of cardiovascular complications.
OBJECTIVE: To determine the prevalence of and factors associated with left ventricular diastolic dysfunction (LVDD) in adult Nigerians with CKD at presentation and to compare findings with those of hypertensive patients with normal renal function.
METHODS: Eighty-six consecutive patients with CKD were studied, comprising 43 hypertensives and 43 age- and sex-matched healthy subjects as controls. Clinical, laboratory, and echocardiographic variables were measured.
RESULTS: Left ventricular diastolic dysfunction was present in 62.8% of CKD patients, 79.1% of hypertensive patients and 25.6% of normal controls (p<0.001). There was a positive correlation between left ventricular diastolic function (LVDF) and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), severity of SBP, severity of DBP in CKD patients but not in hypertensive patients. There was a negative correlation between LVDF and age in CKD patients and hypertensive patients. Linear multiple regression analysis showed age as the only predictor of LVDD.
CONCLUSION: There is a high prevalence of diastolic dysfunction in CKD patients at first presentation to a nephrologist in Nigeria.
E B Arodiwe; I I Ulasi; C K Ijoma; S O Ike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  West African journal of medicine     Volume:  29     ISSN:  0189-160X     ISO Abbreviation:  West Afr J Med     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301891     Medline TA:  West Afr J Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Renal Unit, University of Nigeria Teaching Hospital, Enugu, Nigeria.
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