Document Detail

Left ventricular diastolic filling response to stationary bicycle exercise during pregnancy and the postpartum period.
MedLine Citation:
PMID:  11641659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the effects of pregnancy and of maximal exercise on left ventricular diastolic filling response. STUDY DESIGN: Transmitral pulsed Doppler echocardiography was obtained in 10 healthy women during each trimester of pregnancy and at 12 weeks after delivery. Doppler studies were performed at rest and at each exercise workload. The P-R interval, the early and atrial peak flow velocities, the mitral early deceleration time, and the isovolumetric relaxation time were analyzed. Data are expressed as the mean and standard deviation of the mean. Values obtained during the last trimester of pregnancy were used as the pregnant value; values at the 12 weeks after delivery were used as the nonpregnant value. Paired t -test, analysis of variance, and mixed models were used to determine significance with a probability value of <.05. RESULTS: Pregnancy significantly increased the early and atrial peak flow velocities. Pregnancy decreased the P-R interval, the early deceleration time, and the isovolumetric relaxation time. Exercise significantly decreased these diastolic functions; but pregnancy, in any of the 3 trimesters, did not significantly affect this response. CONCLUSION: Pregnancy increased left ventricular diastolic camber stiffness at rest and shifted left ventricular diastolic filling during exercise from predominantly early to atrial filling. This finding suggests that there is an increase in left ventricular chamber stiffness during maximal upright bicycle exercise in pregnancy.
J C Veille; D W Kitzman; P D Millsaps; P D Kilgo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  185     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2001-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  822-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Analysis of Variance
Cardiac Output
Diastole / physiology
Echocardiography, Doppler
Exercise / physiology*
Exercise Test*
Heart Function Tests
Postpartum Period
Pregnancy / physiology*
Pregnancy Trimester, Third
Reference Values
Sensitivity and Specificity
Ventricular Function, Left / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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