Document Detail

Left ventricular diastolic filling and cardiovascular functional capacity in older men.
MedLine Citation:
PMID:  11038406     Owner:  NLM     Status:  MEDLINE    
We investigated anaerobic threshold (< theta(L)) gas exchange kinetics and maximal oxygen uptake (VO2,max) among older men with reduced left ventricular end-diastolic filling (LVDF). Ten men (mean age, 73 years) with LVDF impairment and low fitness, but without other cardiovascular dysfunction were studied. Treatments compared to control included: 5 days, high intensity exercise training protocol; 5 days, calcium channel blockade (240 mg verapamil); 21 days, detraining/washout; and 5 days, combined treatments. Results indicated no changes in resting left ventricular systolic function with any treatment. Significant resting diastolic function changes included increased early:late flow velocity (control, 0.87; training, 1.28; verapamil, 1.32), and a decreased isovolumic relaxation time (control, 0.10 s; training, 0.08 s; verapamil, 0.08 s). The combined treatments were not additive. Sub-threshold oxygen uptake kinetics (tauVO2, s) were significantly faster following either training or verapamil (tauVO2,control, 62+/-12; tauVO2,training, 44+/-9; tauVO2,verapamil, 48+/-10) and combined treatments (tauVO2, 41+/- 8). V O2,max (ml kg(-1) min(-1)) was significantly increased (control, 21.8+/-2.2; training, 27.3+/-2.2; verapamil, 25.2+/-3.4; combined treatments, 26.9+/-2.3). Increasing ventricular preload with either exercise training or calcium channel blockade was coincident with faster tauVO2 and increased VO2,max.
R J Petrella; D A Cunningham; D H Paterson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  85     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-55     Citation Subset:  IM    
Departments ofFamily Medicine, Physical Medicine and Rehabilitation, Physiology and School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 5C1.
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MeSH Terms
Aging / physiology*
Anaerobic Threshold / physiology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology
Exercise / physiology*
Heart Rate / drug effects
Oxygen / blood,  metabolism
Plasma Volume / drug effects
Ventricular Function, Left / drug effects*,  physiology*
Verapamil / pharmacology*
Reg. No./Substance:
0/Calcium Channel Blockers; 52-53-9/Verapamil; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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