| Left ventricular diastolic filling and cardiovascular functional capacity in older men. | |
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MedLine Citation:
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PMID: 11038406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated anaerobic threshold (< theta(L)) gas exchange kinetics and maximal oxygen uptake (VO2,max) among older men with reduced left ventricular end-diastolic filling (LVDF). Ten men (mean age, 73 years) with LVDF impairment and low fitness, but without other cardiovascular dysfunction were studied. Treatments compared to control included: 5 days, high intensity exercise training protocol; 5 days, calcium channel blockade (240 mg verapamil); 21 days, detraining/washout; and 5 days, combined treatments. Results indicated no changes in resting left ventricular systolic function with any treatment. Significant resting diastolic function changes included increased early:late flow velocity (control, 0.87; training, 1.28; verapamil, 1.32), and a decreased isovolumic relaxation time (control, 0.10 s; training, 0.08 s; verapamil, 0.08 s). The combined treatments were not additive. Sub-threshold oxygen uptake kinetics (tauVO2, s) were significantly faster following either training or verapamil (tauVO2,control, 62+/-12; tauVO2,training, 44+/-9; tauVO2,verapamil, 48+/-10) and combined treatments (tauVO2, 41+/- 8). V O2,max (ml kg(-1) min(-1)) was significantly increased (control, 21.8+/-2.2; training, 27.3+/-2.2; verapamil, 25.2+/-3.4; combined treatments, 26.9+/-2.3). Increasing ventricular preload with either exercise training or calcium channel blockade was coincident with faster tauVO2 and increased VO2,max. |
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Authors:
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R J Petrella; D A Cunningham; D H Paterson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental physiology Volume: 85 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-16 Completed Date: 2000-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 547-55 Citation Subset: IM |
Affiliation:
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Departments ofFamily Medicine, Physical Medicine and Rehabilitation, Physiology and School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 5C1. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology* Anaerobic Threshold / physiology Blood Flow Velocity / drug effects Blood Pressure / drug effects Calcium Channel Blockers / pharmacology Exercise / physiology* Heart Rate / drug effects Humans Male Oxygen / blood, metabolism Plasma Volume / drug effects Ventricular Function, Left / drug effects*, physiology* Verapamil / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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