Document Detail

Left ventricular diastolic dysfunction in patients with metabolic syndrome.
MedLine Citation:
PMID:  22452234     Owner:  NLM     Status:  In-Process    
Metabolic syndrome (MetS), which is a cluster of medical disorders, is common and it is associated with increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the relationship between characteristics of metabolic syndrome and the grade of diastolic dysfunction. The study included 72 patients (29 male and 43 female), who had central obesity and at least two of the other four characteristics of metabolic syndrome according to IDF (International Diabetes Federation) criteria. The exclusion criteria were age above 65, impaired systolic function (left ventricular ejection fraction < 55%) atrial fibrillation, valvular and pericardial heart disease. Diastolic function was determined according to the criteria of the American Society of Echocardiography. There was a positive correlation between the number of characteristics of metabolic syndrome and the diastolic dysfunction grade (p < 0.0001). The positive correlation was found between the grade of diastolic dysfunction and the waist circumference (p < 0.0001), arterial hypertension (p < 0.001). pared glucose tolerance/diabetes (P = 0.0063), and hypertriglyceridemia (p = 0.0262). A low level of high-density lipoprotein did not show a statistically significant correlation. The presence of metabolic syndrome is associated with the presence of diastolic dysfunction. The grade of diastolic dysfunction is dependent on the number of coexisting characteristics of metabolic syndrome. Arterial hypertension, central obesity, hyperglycemia and hypertriglyceridemia showed a significant correlation with the degree of diastolic dysfunction.
Davor Penjasković; Dejan Sakac; Jovanka Dejanović; Radovan Zec; Nada Zec Petković; Anastazija Stojsić Milosavljević
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski pregled     Volume:  65     ISSN:  0025-8105     ISO Abbreviation:  Med. Pregl.     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985249R     Medline TA:  Med Pregl     Country:  Serbia    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
General Hospital Sremska Mitrovica.
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