| Left ventricular diastolic dysfunction in the early stage of chronic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 19782256 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: The disadvantageous effect of kidney dysfunction on left ventricular (LV) diastolic function is still unknown. METHODS: Forty non-chronic kidney disease (CKD) patients and 202 CKD patients, aged 40-89, were examined by standard echocardiography and the new modality of tissue Doppler imaging. All subjects were divided into 5 groups depending on their estimated glomerular filtration rate (GFR: ml/min/BSA). Classifications by GFR were defined as follows: group 1 (more than 90: normal subjects), group 2 (60-89), group 3 (30-59), group 4 (15-29) and group 5 (less than 15). RESULTS: There were no significant differences in LV systolic function among the groups. Mitral E velocity was significantly lower in groups 1-4 (p<0.01-0.02) compared with group 5. Mitral A velocity was higher in groups 2-5 (p<0.01-0.04) compared with group 1. The ratio of mitral E and A velocities (E/A) was significantly higher in group 1 (p<0.02-0.05) compared with groups 2-5. Deceleration time was significantly shorter in groups 1 and 2 (p<0.01-0.02) compared with groups 4 and 5. Furthermore, it was significantly lower in group 5 (p<0.01) compared with group 4. Early diastole velocity of mitral annulus (Ea) by tissue Doppler was also higher in group 1 (9.1+/-2.5; p<0.01-0.04) compared with group 2 (7.9+/-1.7), group 3 (7.9+/-1.6), group 4 (7.5+/-2.1), and group 5 (7.6+/-2.0). Severity of the kidney dysfunction appears to parallel with the rise of E/Ea significantly (p<0.02). A, E/A and Ea could differentiate between groups 1 and 2 with early stage of CKD. CONCLUSIONS: These data suggest that LV diastolic dysfunction was observed even in patients with early stages of chronic kidney dysfunction. Doppler indices combined with conventional and tissue Doppler methods could detect the subtle changes of diastolic function due to kidney dysfunction. |
| | |
Authors:
|
Takenori Otsuka; Makoto Suzuki; Hisao Yoshikawa; Kaoru Sugi |
Related Documents
:
|
11988196 - Frequency, predictors, and consequences of atrioventricular block after mitral valve re... 12079936 - Robotically controlled video-assisted port-access mitral valve surgery. 15084376 - Temporal trends in percutaneous mitral commissurotomy over a 15-year period. 8281646 - Prediction of outcome after valve replacement for rheumatic mitral regurgitation in the... 6094116 - Tinea versicolor: treatment and prophylaxis with monthly administration of ketoconazole. 11924726 - Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by... |
Publication Detail:
|
Type: Journal Article Date: 2009-07-09 |
Journal Detail:
|
Title: Journal of cardiology Volume: 54 ISSN: 1876-4738 ISO Abbreviation: J Cardiol Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
|
Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan. nori3649@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevention of contrast-induced nephropathy by chronic pravastatin treatment in patients with cardiov...
Next Document: Relationship between plaque composition and no-reflow phenomenon following primary angioplasty in pa...