| Left ventricular diastolic dysfunction in idiopathic pulmonary fibrosis: a tissue Doppler echocardiographic [corrected] study. | |
| | |
MedLine Citation:
|
PMID: 18057055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It was hypothesised that, apart from right ventricular (RV) dysfunction, patients with idiopathic pulmonary fibrosis (IPF) also exhibit left ventricular (LV) impairment, which may affect disease progression and prognosis. The aim of the present study was to evaluate LV performance in a cohort of IPF patients using conventional and tissue Doppler ECG. IPF patients exhibiting mild-to-moderate pulmonary arterial hypertension (mean age 65+/-9 yrs; n = 22) and healthy individuals (mean age 61+/-6 yrs; n = 22) were studied. Conventional and tissue Doppler ECG were used for the evaluation of RV and LV systolic and diastolic function. In addition to the expected impairment in RV function, all patients showed a characteristic reversal of LV diastolic filling to late diastole compared with controls (early diastolic peak filling velocity (E)/late diastolic peak filling velocity 0.7+/-0.2 versus 1.5+/-0.1, respectively). Patients with IPF also exhibited lower peak myocardial velocities in early diastole (E(m); 5.7+/-1.1 versus 10.3+/-1.6 cm x s(-1), respectively), higher in late diastole (A(m); 8.9+/-1.3 versus 5.5+/-0.8 cm x s(-1), respectively), lower E(m)/A(m) ratio (0.6+/-0.1 versus 1.9+/-0.5, respectively) and higher E/E(m) ratio (10.8+/-3 versus 6+/-0.6, respectively), all indicative of LV diastolic dysfunction. Moreover, LV propagation velocity was significantly lower in IPF patients (46+/-13 versus 83+/-21 cm x s(-1), respectively). Physicians should be aware that patients with idiopathic pulmonary fibrosis exhibit early impairment of left ventricular diastolic function. |
| | |
Authors:
|
C E Papadopoulos; G Pitsiou; T D Karamitsos; H I Karvounis; T Kontakiotis; G Giannakoulas; G K Efthimiadis; P Argyropoulou; G E Parharidis; D Bouros |
Related Documents
:
|
19435825 - Impact of resistance to thyroid hormone on the cardiovascular system in adults. 16319835 - Structural and functional affection of the heart in protein energy malnutrition patient... 20691835 - Correlation of heart-type fatty acid-binding protein with mortality and echocardiograph... 12710315 - Regional left ventricle mechanical asynchrony in patients with heart disease and normal... 11062605 - Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in ... 3180415 - Nosocomial dysnatremia. |
Publication Detail:
|
Type: Journal Article Date: 2007-12-05 |
Journal Detail:
|
Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 31 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-04-01 Completed Date: 2008-05-06 Revised Date: 2009-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 701-6 Citation Subset: IM |
Affiliation:
|
1st Cardiology Dept, AHEPA University Hospital, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Case-Control Studies Cohort Studies Diastole / physiology Echocardiography, Doppler, Pulsed Female Humans Male Middle Aged Pulmonary Fibrosis / complications, ultrasonography* Ventricular Dysfunction, Left / complications* Ventricular Dysfunction, Right / complications, ultrasonography* |
| Comments/Corrections | |
Comment In:
|
Eur Respir J. 2009 Mar;33(3):702-3; author reply 703-4
[PMID:
19251811
]
|
Erratum In:
|
Eur Respir J. 2008 Aug;32(2):534 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways.
Next Document: Value of chest radiography in phenotyping chronic obstructive pulmonary disease.