Document Detail

Left ventricular contractility in response to upright isometric exercise in heart transplant recipients and healthy men.
MedLine Citation:
PMID:  18277825     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We evaluated left ventricular contractility during upright isometric exercise, in heart transplant recipients (HTRs) and in healthy controls, using ejection fraction and end-systolic pressure/volume ratio indexes. METHODS: Fifteen healthy men (40 +/- 13 years) and 10 HTRs (42 +/- 12 years) underwent dead lift (DL) test at 30% of maximal effort for 3 minutes. Echocardiographic variables were measured during the final 45 seconds. RESULTS: During DL test, HTRs were significantly different (P < .01) from controls in all parameters except end-diastolic volume. DL test had lower mean values of ejection fraction (49.9% +/- 8.3% vs 67.0% +/- 4.3%, respectively) and left ventricular end-systolic pressure/volume ratio (3.5 +/- 0.7 vs 5.5 +/- 1.2, respectively) whereas higher values of end-systolic volume (51.0 +/- 9.4 mL vs 34.1 +/- 5.3 mL, respectively). Importantly, an intergroup effect was found in end-systolic pressure/volume ratio, further signifying differential response of HTRs. End-systolic pressure/volume ratio increased consistently (P < .001) in both groups, whereas the overall main effect of ejection fraction response was not significant. CONCLUSIONS: Left ventricular function during upright isometric exercise displays differential pattern of response in HTRs in comparison with healthy controls. However, cardiac contractility in HTRs remained stable at peak systolic blood pressure produced by the isometric DL exercise. Results suggest that both ejection fraction and end-systolic pressure/volume ratio indexes can be used for assessment of ventricular function in patients after heart transplantation.
Moran Sagiv; Offer Amir; Ehud Goldhammer; David Ben-Sira; Ruthie Amir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  28     ISSN:  1932-7501     ISO Abbreviation:  -     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-03-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
Sports Medicine & Rehabilitation Division, the Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, Israel.
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MeSH Terms
Case-Control Studies
Exercise / physiology*
Heart Transplantation / physiology*
Middle Aged
Myocardial Contraction / physiology*
Stroke Volume
Ventricular Function, Left / physiology*
Ventricular Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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