Document Detail

Left ventricular contractility and energetic cost in disease models--an approach from the pressure-volume diagram.
MedLine Citation:
PMID:  1495163     Owner:  NLM     Status:  MEDLINE    
Left ventricular contractility and the energetic cost of contraction were assessed in various disease models in experimental animals utilizing frameworks of Emax (left ventricular contractility index) and pressure-volume area (PVA, a measure of total left ventricular mechanical energy expenditure) derived from the pressure-volume (P-V) diagram. Under various contractile conditions, PVA linearly correlates with myocardial oxygen consumption per beat (VO2) in a load-independent manner. The reciprocal of the slope of the linear VO2-PVA relation indicates "contractile efficiency" (the energy transduction efficiency from oxygen to total mechanical energy). It was similar between dog and rabbit hearts (about 40%) and was not significantly affected by enhanced contractility with calcium, epinephrine, or cardiac cooling, or by depressed contractility with propranolol, decreased coronary perfusion pressure, or stunned myocardium. However, in thyrotoxic rabbit hearts contractile efficiency was significantly depressed compared to normal hearts. On the other hand, the VO2 intercept of the VO2-PVA relation (PVA-independent VO2), which reflects VO2 for non-mechanical activities such as excitation-contraction coupling and basal metabolism, positively correlates with Emax. Therefore, the ratio of an increase in PVA-independent VO2 to an increase in Emax indicates "oxygen cost of contractility". Oxygen cost of contractility was higher in stunned myocardium than in normal hearts, suggesting that the energy cost of calcium handling is elevated in stunned myocardium. Thus, using the frameworks of Emax and PVA, we can interconnect cardiac mechanics and energetics. Further, using the concepts of contractile efficiency and oxygen cost of contractility, we can approach the pathogenesis of variously altered contractile conditions.
Y Goto; S Futaki; O Kawaguchi; K Hata; T Takasago; A Saeki; T Nishioka; H Suga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  56     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  716-21     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center, Suita, Japan.
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MeSH Terms
Calcium / pharmacology*
Disease Models, Animal
Epinephrine / pharmacology
Heart Diseases / physiopathology*
Myocardial Contraction / drug effects*
Oxygen Consumption
Propranolol / pharmacology*
Quinolines / pharmacology
Reg. No./Substance:
0/Quinolines; 51-43-4/Epinephrine; 525-66-6/Propranolol; 7440-70-2/Calcium; 81840-15-5/vesnarinone

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