Document Detail

Left ventricular assist devices: evolving devices and indications for use in ischemic heart disease.
MedLine Citation:
PMID:  15502508     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The mortality with end-stage heart failure is extremely high, especially when patients become refractory to conventional medical therapy and require frequent hospitalization. Ischemic heart disease remains the primary cause of advanced heart failure. Mechanical pumps or devices have been developed called ventricular assist devices and are being used to support an increasing number of patients with refractory heart failure. RECENT FINDINGS: The use of ventricular assist devices has evolved from initially only support of patients unable to be weaned from a heart-lung machine after cardiac surgery to use now as a bridge to a heart transplant, including patients with acute myocardial infarction and shock and severe pulmonary hypertension. More recently, they have been proven as a definitive alternative for patients not eligible for heart transplantation. There are new devices being examined in clinical trials, including a change from pusher-plate to devices with axial flow technology that are much smaller and easier to implant. Outcomes with their use are improving rapidly as the devices become more reliable and more is learned about the importance of candidate selection. SUMMARY: This review describes current indications for the use of these devices, the types of pumps now available, criteria for initiating ventricular assist device support, complications of their use, and new applications such as a platform for stem cell therapy for treatment of end-stage heart failure.
Katherine Lietz; Leslie W Miller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  19     ISSN:  0268-4705     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-05-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-8     Citation Subset:  IM    
Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Cardiac Surgical Procedures / adverse effects
Heart Failure / therapy
Heart-Assist Devices / adverse effects,  standards*
Hemorrhage / etiology
Infection / etiology
Kidney Failure / etiology
Myocardial Ischemia / therapy*
Ventricular Dysfunction, Left / surgery,  therapy*
Ventricular Dysfunction, Right / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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