| Left ventricular apical thrombus and myocardial viability: a dobutamine stress echocardiographic study. | |
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MedLine Citation:
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PMID: 11000589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this article was to determine whether the presence of left ventricular apical thrombus is a marker of nonviable myocardium. Reduced coronary blood flow secondary to atherosclerosis may result in chronic reversible left ventricular wall-motion abnormalities. Severe regional abnormalities also predispose to formation of left ventricular thrombus. The relationship between left ventricular apical thrombus and myocardial viability has not been previously described. Eighty patients with coronary artery disease and chronic left ventricular dysfunction were studied by dobutamine stress echocardiography. Left ventricular apical thrombus was identified using echocardiographic criteria. Wall-motion analysis was performed using a standard 16-segment model and ejection fraction was calculated. As a result, 48 patients (60%) had definite or highly suspicious findings for left ventricular thrombus (group 1), and 32 patients (40%) had no thrombus (group 2). Group 1 had significantly higher composite (54.0 +/- 5.8 vs 43.3 +/- 6.4) and apical (6.0 +/- 2.7 vs 12.4 +/- 3.4) wall-motion scores compared to those in group 2 (P = 0.01). Thirty-two patients (67%) in group 1 demonstrated no contractile reserve in the apical segments, consistent with lack of viability, versus eight patients (25%) in group 2 (P = 0.0003). The number of viable apical segments per patient was significantly less in group 1 (0.7 +/- 1.2) versus group 2 (1.8 +/- 1.3) (P = 0.01). Left ventricular apical thrombus is more likely to be present when there is absence of myocardial viability in the corresponding segments. |
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Authors:
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D A Cusick; R O Bonow; F A Chaudhry |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 17 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-11-29 Completed Date: 2000-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-54 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Chi-Square Distribution Coronary Disease / complications Dobutamine / diagnostic use Echocardiography* Exercise Test Female Heart Diseases / etiology, ultrasonography* Heart Ventricles / ultrasonography Humans Male Middle Aged Myocardial Contraction Probability Risk Assessment Stroke Volume Thrombosis / etiology, ultrasonography* Ventricular Dysfunction, Left / etiology, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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