Document Detail

Left ventricular and aortic root structure and function changes with beta blocker antihypertensive therapy. A one-year double blind study of celiprolol and metoprolol.
MedLine Citation:
PMID:  7607766     Owner:  NLM     Status:  MEDLINE    
Using echocardiographic and Doppler methodology, we evaluated the effects of celiprolol 200-400 mg/day and metoprolol 100-200 mg/day, given for one year, on haemodynamics, left ventricular structure and function, and aortic root distensibility in 40 hypertensive patients. Total peripheral resistance was unchanged with metoprolol (-1.7%) but decreased with celiprolol (-11.2%), a significant difference between the two treatments (P = 0.01). Left ventricular mass index was reduced by 5.7% in those patients receiving metoprolol and by 11.8% in those receiving celiprolol (P < 0.001). Cardiac index fell significantly with metoprolol and marginally with celiprolol (-13.9% vs. 5.9%, P = 0.003). Left ventricular diastolic function-as shown by the transmitral early to late peak filling velocity ratio-was not altered with metoprolol, but a significant increase (17%, P = 0.2) was seen with celiprolol. Both metoprolol and celiprolol increased aortic root distensibility, with celiprolol having a significantly greater effect (80% vs. 30%, P < 0.01). We conclude that, in comparison to metoprolol, long term antihypertensive therapy with celiprolol improves left ventricular diastolic and aortic root function, whilst reducing total peripheral resistance and left ventricular hypertrophy.
G P Vyssoulis; M A Valiouli; E A Karpanou; P K Toutouzas
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  49     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-14     Completed Date:  1995-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  45-54     Citation Subset:  IM    
Department of Cardiology, University of Athens, Greece.
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MeSH Terms
Aorta / drug effects
Celiprolol / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Echocardiography, Doppler, Pulsed
Hemodynamics / drug effects*
Hypertension / drug therapy*
Metoprolol / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Prospective Studies
Ventricular Function, Left / drug effects*,  physiology
Reg. No./Substance:
37350-58-6/Metoprolol; 56980-93-9/Celiprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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