Document Detail

Left ventricular aneurysm in the scope of gated perfusion SPECT: accuracy of detection and ejection fraction calculation.
MedLine Citation:
PMID:  18278565     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this trial was to investigate the capacity of gated perfusion SPECT (GPS) to detect left ventricular aneurysm (ANV) by comparing QGS and 4D-MSPECT (4DM) algorithms with radionuclide ventriculography (RVG). Secondarily, the comparison of GPS ejection fraction (EF) measurements with those of contrast left ventriculography (LVG) and RVG was aimed. METHODS: Twenty-five patients with ANV confirmed by LVG were studied. The patients underwent RVG and rest Tc-99m-tetrofosmin GPS 1 week after LVG. A 9-segment model was used both in RVG and GPS evaluation. Aneurysm was defined by scoring the wall motion (WM) and phase analysis in RVG; perfusion, wall thickening and WM in GPS. RESULTS: The detection rate of ANV was 96%, 84% and 52% for RVG, QGS and 4DM, respectively. The LVG mean EF (43.52% +/- 16.93%) was significantly higher (P < 0.01) than those of RVG (29.40% +/- 10.90), QGS (30.04% +/- 13.25%) and 4DM (34.92% +/- 13.01%). Moderate to high EF correlation values were obtained between LVG and GPS (r = 0.71-0.79) and GPS-RVG (r = 0.69). There was no significant EF difference between the radionuclide methods except between 4DM-EF and RVG-EF (5.52%, P < 0.05). Wide Bland-Altman limits were observed between the radionuclide methods in EF comparisons (range: 30.5-38.5%). CONCLUSION: GPS seems to have a role in the non-invasive investigation of ANV. QGS-GPS proved to be more reliable (84%) than 4DM-GPS (52%) in the ANV detection. The localization and the extent of the aneurysm itself as well as perfusion and function of adjacent segments may affect aneurysm diagnosis by means of GPS. RVG, QGS-GPS and 4DM-GPS seem not to be interchangeable for routine EF calculation in ANV patients.
Fevziye Canbaz; Tarik Basoglu; Kenan Durna; Sibel Ucak Semirgin; Sevgi Canbaz
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-02-16
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  24     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-96     Citation Subset:  IM    
Department of Nuclear Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
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MeSH Terms
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography*
Coronary Aneurysm / physiopathology,  radionuclide imaging*
Heart Ventricles / physiopathology,  radionuclide imaging
Image Interpretation, Computer-Assisted
Middle Aged
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Predictive Value of Tests
Radionuclide Ventriculography*
Radiopharmaceuticals / diagnostic use*
Reproducibility of Results
Stroke Volume*
Ventricular Function, Left*
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

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