| Left ventricular anatomy and function in primary aldosteronism and renovascular hypertension. | |
| | |
MedLine Citation:
|
PMID: 9433512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Left ventricular hypertrophy (LVH) is a common finding in hypertension and represents a detrimental outcome since it is associated with increased morbidity and mortality. For similar elevation of blood pressure the severity and type of LVH vary considerably in relation to several factors. Compelling evidence suggests that both the renin-angiotensin system (RAS) and the aldosterone excess play an important role in the pathogenesis of LVH, since experimentally angiotensin II has been found to cause myocardial cells hypertrophy and/or hyperplasia and excess aldosterone has been related to extracellular matrix and collagen deposition and therefore to myocardial fibrosis. Secondary forms of hypertension offer models for investigating the relative role of the RAS and aldosterone on the heart in humans. Being rare in the population of hypertensive patients, they furnish an example of the so called Bateson's approach to the understanding of diseases "Treasure your exceptions." In this paper, we review the data concerning the LV changes in primary aldosteronism and renovascular hypertension and discuss the insight that they have provided into the pathogenesis of LVH. |
| | |
Authors:
|
A C Pessina; A Sacchetto; G P Rossi |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 432 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1997 |
Date Detail:
|
Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 63-9 Citation Subset: IM |
Affiliation:
|
Department of Clinical & Experimental Medicine, University of Padua Medical School. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenalectomy Aldosterone / physiology Animals Heart / physiology, physiopathology Heart Ventricles / anatomy & histology* Humans Hyperaldosteronism / complications, physiopathology* Hypertension / complications, physiopathology* Hypertension, Renovascular / complications, physiopathology* Hypertrophy, Left Ventricular / etiology*, physiopathology Renin-Angiotensin System Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
|
52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Local angiotensin II and myocardial fibrosis.
Next Document: Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac...