Document Detail

Left ventricle load impedance control by apical VAD can help heart recovery and patient perfusion: a numerical study.
MedLine Citation:
PMID:  17515714     Owner:  NLM     Status:  MEDLINE    
The aim of this work is to investigate the dependence between left ventricular load impedance control by an apical ventricular assist device (VAD) and the consequent benefits for pathological heart recovery. A pathological left ventricle with 34% contractility has been simulated in the assisted and nonassisted conditions. By means of an extended Kalman filter, left ventricular pressure-volume loops have been partially estimated and ventricular as well as circulatory quantities inferred. The heart operation mode, based on cardiac energetic criteria, is imposed by controlling the VAD filling phase. In the assisted condition, results show that the left ventricle end-diastolic volume, left atrial pressure, and wall stress all decrease; stroke volume, ejection fraction, ventricular efficiency, aortic pressure, and cardiac output all increase. Benefits are also evident for the right ventricle and systemic and pulmonary circulation. The strategy outlined in this work also shows that good results for heart recovery are achievable and a possible way to improve the functional properties of commercial pulsatile VADs.
Francesco M Colacino; Francesco Moscato; Fabio Piedimonte; Maurizio Arabia; Guido A Danieli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  53     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-77     Citation Subset:  IM    
Department of Mechanical Engineering, University of Calabria, Rende, Italy.
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MeSH Terms
Cardiography, Impedance*
Heart-Assist Devices*
Models, Cardiovascular*
Myocardial Contraction / physiology
Pulsatile Flow / physiology
Recovery of Function / physiology
Ventricular Dysfunction, Left / physiopathology*,  surgery
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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