| Left ventricle haemodynamics and vaso-active hormones during graded supine exercise in healthy male subjects. | |
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MedLine Citation:
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PMID: 8789576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricle systolic and diastolic functional parameters were measured by gated equilibrium radionuclide cardiography in 12 healthy men (age 33-51 years) at rest and during graded supine exercise. The leftventricle end-diastolic volume showed an initial small (11%) increase during low submaximal exercise [from mean 163 (SD 40) at rest to mean 181 (SD 48) ml], while left ventricle end-systolic volume decreased successively [from mean 59 (SD 19) to mean 39 (SD 21) ml] with increasing exercise. Stroke volume was therefore elevated at all exercise levels compared with rest [mean 104 (SD 23) ml], and the peak value [mean 128 (SD 33) ml] was found at the lowest exercise level, contributing 40% to the initial increase in cardiac output. Cardiac output increased from mean 6.2 (SD 1.4) at rest to mean 20.2 (SD 5.0) l.min-1 at maximum. Left ventricle peak ejection and peak filling rates increased from mean 449 (SD 89) and mean 442 (SD 85) ml.s-1 at rest to mean 996 (SD 227) and mean 1255 (SD 333) ml.s-1, respectively, at maximum. The myocardium oxygen consumption, assumed to be proportional to the sum of the stroke work and the potential energy, increased fourfold, but absolute values were twice as high as expected, indicating that extrapolation from data obtained in dog hearts (as we have done) cannot be directly applied to humans. Selected vaso-active hormones were measured at all exercise intensities. Noradrenaline (NA), adrenaline (A) and angiotensin II (AII) concentrations showed a very pronounced increase at maximal exercise compared with the preceding lower intensites, while atrial natriuretic factor (ANF) and cyclic guanosinemonophosphate (cGMP) concentrations showed a more continuous increase, and dopamine (DA) remained almost unchanged. This speaks in favour of a crucial role for NA, A and AII in preserving blood pressure at maximum exercise, while DA probably has no importance for the cardiovascular homeostasis during exercise. Increases in concentrations of ANF and cGMP were highly correlated (r = 0.86). Our data supported the opinion that there is a cardiac limitation to maximal performance connected to the cardiac pumping capacity. |
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Authors:
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I L Kanstrup; J Marving; N Gadsbøll; H Lønborg-Jensen; P F Høilund-Carlsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 72 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1995 |
Date Detail:
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Created Date: 1996-10-18 Completed Date: 1996-10-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 86-94 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II / blood Atrial Natriuretic Factor / blood Cardiac Output Cyclic GMP / blood Dopamine / blood Epinephrine / blood Exercise / physiology* Hemodynamics* Hormones / blood* Humans Male Middle Aged Norepinephrine / blood Oxygen Consumption Stroke Volume Supine Position* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor |
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