Document Detail


Left-sided grade 3 varicocele may affect the biological function of the epididymis.
MedLine Citation:
PMID:  24354516     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective.Varicocele is present in approximately 30-40% of men evaluated for infertility and in 10-20% of the general male population, but the association between varicocele, compromised semen quality and male infertility remains unclear. This indicates that varicocele may impair spermatogenesis or in some other way mitigate sperm quality. Better understanding of criteria for the selection of men who will benefit from varicocele repair would improve the clinical management of men with impaired semen quality and varicocele. Material and methods. To further understand the effect of varicocele repair by embolization in men with grade 3 varicocele, 50 men referred for infertility with varicocele were evaluated before and after embolization. Results.There was a significant improvement in total sperm count (25.5 ± 4.7 million to 78 ± 11 million, p < 0.001) and sperm motility (slowly and rapidly progressive) (31.5 ± 2.9% to 45 ± 2.5%, p < 0.001) after spermatic vein embolization, comparing baseline to 3 month post-treatment follow-up data. Furthermore, alpha-glucosidase (specific epididymis-derived protein) increased from 61.7 ± 5.7 U to 84.7 ± 7.0 U (p < 0.05) and sperm droplets decreased from 14.2 ± 1.5% to 11.0 ± 1.0% (p < 0.05). Conclusion. The results indicate improved epididymal function and suggest that left-sided grade 3 varicocele may affect the epididymis in addition to effects on the testis.
Authors:
Mikael Lehtihet; Stefan Arver; Bo Kalin; Ulrik Kvist; Ake Pousette
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-19
Journal Detail:
Title:  Scandinavian journal of urology     Volume:  -     ISSN:  2168-1813     ISO Abbreviation:  Scand J Urol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101587186     Medline TA:  Scand J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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