| Left-right patterning in the C. elegans embryo: Unique mechanisms and common principles. | |
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MedLine Citation:
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PMID: 21509174 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The development of bilateral symmetry during the evolution of species probably 600 million years ago brought about several important innovations: It fostered efficient locomotion, streamlining and favored the development of a central nervous system through cephalization. However, to increase their functional capacities, many organisms exhibit chirality by breaking their superficial left-right (l-r) symmetry, which manifests in the lateralization of the nervous system or the l-r asymmetry of internal organs. In most bilateria, the mechanisms that maintain consistent l-r asymmetry throughout development are poorly understood. This review highlights insights into mechanisms that couple early embryonic l-r symmetry breaking to subsequent l-r patterning in the roundworm Caenorhabditis elegans. A recently identified strategy for l-r patterning in the early C. elegans embryo is discussed, the spatial separation of midline and anteroposterior axis, which relies on a rotational cellular rearrangement and non-canonical Wnt signaling. Evidence for a general relevance of rotational/torsional rearrangements during organismal l-r patterning and for non-canonical Wnt signaling/planar cell polarity as a common signaling mechanism to maintain l-r asymmetry is presented. |
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Authors:
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Christian Pohl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Communicative & integrative biology Volume: 4 ISSN: 1942-0889 ISO Abbreviation: Commun Integr Biol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-04-21 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101478473 Medline TA: Commun Integr Biol Country: United States |
Other Details:
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Languages: eng Pagination: 34-40 Citation Subset: - |
Affiliation:
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Developmental Biology Program; Sloan-Kettering Institute; New York, NY USA. |
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