Document Detail


Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination.
MedLine Citation:
PMID:  16289136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cellular and molecular left-right differences that are present in the mesodermal heart fields suggest that the heart is lateralized from its inception. Left-right asymmetry persists as the heart fields coalesce to form the primary heart tube, and overt, morphological asymmetry first becomes evident when the heart tube undergoes looping morphogenesis. Thereafter, chamber formation, differentiation of the inflow and outflow tracts, and position of the heart relative to the midline are additional features of heart development that exhibit left-right differences. Observations made in human clinical studies and in animal models of laterality disease suggest that all of these features of cardiac development are influenced by the embryonic left-right body axis. When errors in left-right axis determination happen, they almost always are associated with complex congenital heart malformations. The purpose of this review is to highlight what is presently known about cardiac development and upstream processes of left-right axis determination, and to consider how perturbation of the left-right body plan might ultimately result in particular types of congenital heart defects.
Authors:
Ann F Ramsdell
Related Documents :
16461056 - Cardiac conduction disturbances seen after transcatheter device closure of muscular ven...
557466 - Congenital pericardial diaphragmitic hernia and multiple cardiac defects in a litter of...
9056626 - Isolated pontine infarctions with prominent ipsilateral midfacial sensory signs.
19857356 - The gerbode defect: the significance of a left ventricular to right atrial shunt.
9259906 - Perinatal myocardial infarction in a newborn with a structurally normal heart.
3836876 - Long-term coenzyme q10 therapy: a major advance in the management of resistant myocardi...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-11
Journal Detail:
Title:  Developmental biology     Volume:  288     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-20     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology and Anatomy, School of Medicine and Program in Women's Studies, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA. ramsdell@musc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology*
Heart / embryology*
Heart Defects, Congenital / embryology*,  physiopathology
Humans
Grant Support
ID/Acronym/Agency:
HL73270/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocyte...
Next Document:  Expression and hormonal regulation of calcyclin-binding protein (CacyBP) in the mouse uterus during ...