| Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. | |
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MedLine Citation:
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PMID: 11376438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proper morphogenesis and positioning of internal organs requires delivery and interpretation of precise signals along the anterior-posterior, dorsal-ventral, and left-right axes. An elegant signaling cascade determines left- versus right-sided identity in visceral organs in a concordant fashion, resulting in a predictable left-right (LR) organ asymmetry in all vertebrates. The complex morphogenesis of the heart and its connections to the vasculature are particularly dependent upon coordinated LR signaling pathways. Disorganization of LR signals can result in myriad congenital heart defects that are a consequence of abnormal looping and remodeling of the primitive heart tube into a multi-chambered organ. A framework for understanding how LR asymmetric signals contribute to normal organogenesis has emerged and begins to explain the basis of many human diseases of LR asymmetry. Here we review the impact of LR signaling pathways on cardiac development and congenital heart disease. |
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Authors:
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I S Kathiriya; D Srivastava |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: American journal of medical genetics Volume: 97 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-05-28 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: United States |
Other Details:
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Languages: eng Pagination: 271-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75390-9148, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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embryology,
genetics Animals Body Patterning / genetics Chick Embryo Fetal Heart / growth & development*, ultrastructure Fetal Proteins / genetics, physiology Gene Expression Regulation, Developmental* Heart / embryology Heart Defects, Congenital / embryology*, genetics Homeodomain Proteins / genetics, physiology Humans Mice Morphogenesis / genetics* Nuclear Proteins* Paired Box Transcription Factors Situs Inversus / embryology, genetics Transcription Factors / genetics, physiology Viscera / abnormalities Xenopus laevis / embryology Zebrafish / embryology |
| Chemical | |
Reg. No./Substance:
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0/Fetal Proteins; 0/Homeodomain Proteins; 0/Nuclear Proteins; 0/Paired Box Transcription Factors; 0/Transcription Factors; 0/homeobox protein PITX1; 0/homeobox protein PITX3; 184787-43-7/homeobox protein PITX2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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