Document Detail


Left-handed helical preference in an achiral peptide chain is induced by an L-amino acid in an N-terminal Type II beta-turn.
MedLine Citation:
PMID:  23316729     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Oligomers of the achiral amino acid Aib adopt helical conformations in which the screw-sense may be controlled by a single N-terminal residue. Using crystallographic and NMR techniques, we show that the left- or right-handed sense of helical induction arises from the nature of the beta-turn at the N terminus: the tertiary amino acid L-Val induces a left handed Type II beta-turn in both the solid state and in solution, while the corresponding quaternary amino acid L-alpha-methylvaline induces a right handed Type III beta-turn.
Authors:
Matteo De Poli; Marta De Zotti; James Raftery; Juan A Aguilar; Gareth A Morris; Jonathan Clayden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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