| Left coronary pressure-flow relations of the beating and arrested rabbit heart at different ventricular volumes. | |
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MedLine Citation:
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PMID: 9876320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS: Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an intra-ventricular balloon were used. The left coronary artery was separately perfused via a cannula in the left main coronary artery. The slopes and the intercepts of left coronary pressure-flow relations were determined in the beating and arrested heart at different chamber volumes. A 3-factor design with repeated measures was used to compare the effect of three factors: phase of contraction (systole and diastole), chamber volume (V0 and V1, left ventricular end-diastolic pressure 1.4 and 20 mm Hg, respectively) and the type of contraction (beating and arrested; a measure of capacitive effects). RESULTS: The phase of contraction has a significant effect on the intercepts (> 40 mmHg, p = 0.00032) but not on the slopes of the pressure-flow relations. Chamber volume had a small effect on the intercepts (< 5 mm Hg, p = 0.037), but not on the slopes of the pressure-flow relations. The type of contraction has a significant effect on the slopes (approximately 10%, p = 0.00021) but not on the intercepts of the pressure-flow relations. CONCLUSIONS: In the isolated Tyrode perfused rabbit heart left coronary pressure-flow relations are mainly determined by contraction, while left ventricular chamber volume and capacitive effects contribute little. |
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Authors:
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P Sipkema; J J Takkenberg; P E Zeeuwe; N Westerhof |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 40 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-02-02 Completed Date: 1999-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 88-95 Citation Subset: IM |
Affiliation:
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Laboratory for Physiology, Vrije Universiteit (ICaR-VU), Amsterdam, The Netherlands. p.sipkema.physiol@med.vu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / physiology* Diastole Heart Arrest / physiopathology* Male Myocardial Contraction / physiology* Perfusion Rabbits Stroke Volume / physiology* Systole Ventricular Pressure / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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