Document Detail

Left cerebral hemisphere hypodensity in discordant schizophrenic twins. A controlled study.
MedLine Citation:
PMID:  3606328     Owner:  NLM     Status:  MEDLINE    
Eleven identical (monozygotic) twin pairs discordant for schizophrenia and 18 unselected control monozygotic twin pairs received a computed tomographic scan. Brain absorption density was determined on quadrants at five slice levels using a fully automatic program that eliminated cerebrospinal fluid spaces from analysis. There was no difference in brain density among schizophrenics, co-twins, and controls. There was a significant difference in right vs left hemisphere asymmetry of density across diagnostic groups. Overall, the left hemisphere was less dense than the right in the schizophrenics, while the reverse was found for the co-twins and controls. These results support the hypothesis of left hemisphere dysfunction in schizophrenia and suggest that it is an environmentally acquired, rather than genetic trait.
M A Reveley; A M Reveley; R Baldy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  44     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-24     Completed Date:  1987-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  AIM; IM    
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MeSH Terms
Absorptiometry, Photon
Brain / physiopathology,  radiography*
Diseases in Twins*
Functional Laterality* / physiology
Schizophrenia / diagnosis,  genetics*,  physiopathology
Tomography, X-Ray Computed

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