| Left bundle branch block and mortality in patients with acute heart failure syndrome: a substudy of the EFICA cohort. | |
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MedLine Citation:
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PMID: 20028696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: In patients with chronic heart failure (CHF), left bundle branch block (LBBB) is associated with an increased risk of cardiovascular mortality. We aimed to investigate the association of LBBB with short- and long-term outcome in patients discharged after a de novo episode of acute heart failure (AHF) or AHF complicating a mild CHF. METHODS AND RESULTS: Patients with no history of New York Heart Association class III and IV CHF, who were admitted for a severe AHF episode and enrolled in the prospective observational EFICA study (n = 403), were included. Left bundle branch block prevalence was 16%. Patients with LBBB had a higher prevalence of dilated cardiomyopathy (23 vs. 10%, P < 0.005), a higher percentage of AHF episodes without identified precipitating factor (15 vs. 2%, P < 0.001), and were less likely to present increased markers of cardiac injury (41 vs. 56%, P = 0.04). The 4-week mortality was 24.8% with no difference between LBBB and no LBBB patients. Left bundle branch block was however an independent predictor of 1-year mortality in the 4-week survivors [hazards ratio (95% confidence interval) = 2.01 (1.12-3.64), P = 0.02]. CONCLUSION: Long-term outcome of patients surviving a severe episode of de novo AHF or AHF complicating a mild CHF is worsened by LBBB. These patients may constitute a subgroup at high risk in whom specific therapeutic solutions should be investigated. |
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Authors:
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Etienne Huvelle; Renaud Fay; François Alla; Alain Cohen Solal; Alexandre Mebazaa; Faiez Zannad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-21 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2011-01-20 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 156-63 Citation Subset: IM |
Affiliation:
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CIC-INSEM-CHU, Nancy, Hôpital Jeanne d'Arc, BP 90303, 54201 Toul Cedex, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bundle-Branch Block / epidemiology, mortality* Cohort Studies Confidence Intervals Female France / epidemiology Heart Failure / epidemiology, mortality* Humans Kaplan-Meier Estimate Male Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors |
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