| Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis. | |
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MedLine Citation:
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PMID: 20526641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early detection of pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) is essential as it leads to substantial morbidity and mortality irrespective of its etiology. The aim of our study was to determine whether noninvasive biochemical and/or echocardiographic indices can predict the presence of PH in these patients. We prospectively studied 66 patients (mean age of 57.7 +/- 12.1 years, 63 women) with SSc without clinical manifestations of heart failure. All patients underwent standard and tissue Doppler echocardiography. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) and asymmetric dimethylarginine (ADMA) levels were also measured. In 24 (36%) patients, the diagnosis of PH was established by echocardiography (systolic pulmonary artery pressure value > or =40 mmHg). Left atrial (LA) volume, NT-proBNP, ADMA, ratio of early transmitral filling velocity to early diastolic velocity of the mitral annulus (mitral E/E (m)), and right ventricular myocardial performance index (MPI) were univariate predictors of PH. In multivariate analysis, NT-proBNP, LA volume, and right ventricular MPI were independent predictors of PH in SSc patients. LA volume and NT-proBNP may be useful noninvasive markers for the prediction of elevated pulmonary artery pressure in patients with SSc. These parameters should be considered when assessing this population for risk stratification and for identification of patients demanding further investigation and institution of specific therapy for the disease at the time when it is most likely to be effective. |
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Authors:
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Theodoros Dimitroulas; Georgios Giannakoulas; Klio Papadopoulou; Tilemahos Sfetsios; Haralambos Karvounis; Hariklia Dimitroula; Despina Parcharidou; Georgios Koliakos; Alexandros Garyfallos; Ioannis Styliadis; Loukas Settas |
Publication Detail:
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Type: Journal Article Date: 2010-06-05 |
Journal Detail:
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Title: Clinical rheumatology Volume: 29 ISSN: 1434-9949 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Germany |
Other Details:
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Languages: eng Pagination: 957-64 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, AHEPA University Hospital, Stilp. Kiriakidi 1, 54636, Thessaloniki, Greece. dimitroul@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arginine / analogs & derivatives, blood Biological Markers / blood Blood Pressure / physiology Cross-Sectional Studies Female Follow-Up Studies Heart Atria / pathology*, ultrasonography Humans Hypertension, Pulmonary / blood*, etiology, physiopathology* Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Predictive Value of Tests Prospective Studies Pulmonary Artery / physiopathology Scleroderma, Systemic / complications* Ventricular Dysfunction, Right / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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