Document Detail

Left atrial receptor inhibition of cardiac efferent vagal activity in the dog.
MedLine Citation:
PMID:  729206     Owner:  NLM     Status:  MEDLINE    
1. The tachycardia produced by atrial receptor stimulation has been reported to be 'solely' due to an increased sympathetic activity, but not inhibitable by propranolol. We examined the effect of left atrial balloon inflation in chloralose-anaesthetized dogs on heart rate with and without propranolol (1.0 mg/kg) and on the activity in single cardiac efferent fibres of the vagus nerve. 2. Propranolol reduced the cardiac response to balloon inflation by one-third, but did not abolish the tachycardia. Efferent cardiac vagal activity was 3.8 +/- 0.4 spikes/s and 2.3 +/- 0.7 spikes/s prior to and during balloon inflation respectively. 3. It was concluded that the left atrial receptors produce a tachycardia by decreasing cardiac parasympathetic and increasing sympathetic efferent activities.
L W Chapman; U Mittman; C Prickett; W Richmond
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  5     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1978 Sep-Oct
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Efferent Pathways / physiology*
Heart / innervation*
Heart Atria / innervation
Heart Rate / drug effects
Propranolol / pharmacology*
Receptors, Drug / physiology*
Vagus Nerve / physiology*
Reg. No./Substance:
0/Receptors, Drug; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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