Document Detail

Left atrial performance indices in chronic mitral valve disease.
MedLine Citation:
PMID:  8564003     Owner:  NLM     Status:  MEDLINE    
Multidimensional left atrial (LA) performance indices have not been extensively studied in chronic mitral valve disease. LA maximal volume, stroke volume (LA volume at atrial systole minus LA minimal volume), LA ejection fraction (stroke volume/volume at atrial systole) and A-wave velocity, were measured in 14 patients with mitral stenosis (mean mitral valve area 1.5 cm2); 14 patients with chronic mitral regurgitation all in sinus rhythm; and were compared to 20 age and sex matched normal control subjects using biplane transthoracic echo and pulsed Doppler. Although LA volumes--maximal and at onset of atrial systole--were greater in mitral regurgitation and mitral stenosis (p < 0.01) compared to normal subjects, LA ejection fraction was not statistically different among the three groups. LA stroke volume was greater in mitral regurgitation and mitral stenosis compared to normal subjects, p < 0.01. LA kinetic energy (LAKE) = 1/2 mv2 (m = LA stroke volume x 1.06, blood's specific gravity, v = A wave velocity) was increased in mitral stenosis and mitral regurgitation compared to normal subjects (p < 0.001). An inverse correlation (r = 0.66, p < 0.01) was present between LAKE and mitral valve area in mitral stenosis. It is concluded that LA function, a complex interplay of multiple factors, requires multidimensional methods of analysis beyond standard measurements of size and volume, which provide additional insight into normal LA function, and better definition of LA function changes involved in the natural history of chronic mitral valve disease.
H Boudoulas; D Boudoulas; E A Sparks; A C Pearson; H N Nagaraja; C F Wooley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  4 Suppl 2     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-04     Completed Date:  1996-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S242-7; discussion S248     Citation Subset:  IM    
Ohio State University Medical Center, Division of Cardiology, Columbus 43210, USA.
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MeSH Terms
Atrial Function, Left* / physiology
Chronic Disease
Echocardiography, Doppler
Heart Atria / anatomy & histology,  ultrasonography
Middle Aged
Mitral Valve Insufficiency / physiopathology*
Mitral Valve Stenosis / physiopathology*
Reference Values
Grant Support
MO1 R 00034//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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