Document Detail


Left atrial hypertension causes pleural effusion formation in unanesthetized sheep.
MedLine Citation:
PMID:  2764149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of left atrial pressure (LAP) elevation on the formation of pleural effusion in unanesthetized sheep. We prepared the animals by placing catheters in the left atrium, pulmonary artery, femoral artery, and vein. We also placed a balloon catheter in the left atrium. After a recovery period of at least 1 wk, we measured LAP, pulmonary artery pressure (PAP), systemic arterial pressure, systemic venous pressure, cardiac output, plasma protein concentration, and plasma colloid osmotic pressure (pi c). We calculated capillary pressure (Pc) as 0.5(PAP - LAP). We then elevated LAP such that Pc-pi c was between -10 and 19.5 mmHg for 6-24 h. At the end of the experiment, we killed the sheep and measured the volume and protein concentration of the right pleural effusion. We also determined the extravascular fluid to blood free dry weight of the right lung. We found that pleural effusions and pulmonary edema formed when Pc-pi c greater than 5 mmHg. We also found that the pleural effusion volume correlated with the amount of pulmonary edema. Our data show that elevated LAP may cause pleural effusions, but only after pulmonary edema has developed.
Authors:
S Allen; J Gabel; R Drake
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-14     Completed Date:  1989-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H690-2     Citation Subset:  IM    
Affiliation:
Center for Microvascular and Lymphatic Studies, University of Texas Medical School, Houston 77030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Proteins / analysis
Capillaries / physiopathology
Heart Atria / physiopathology
Hypertension / complications,  physiopathology*
Pleural Effusion / etiology,  physiopathology*
Pulmonary Artery / physiopathology
Pulmonary Circulation*
Sheep
Grant Support
ID/Acronym/Agency:
HL-01999/HL/NHLBI NIH HHS; HL-27367/HL/NHLBI NIH HHS; HL-36635/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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