Document Detail

Left atrial appendage-occluding devices for stroke prevention in patients with nonvalvular atrial fibrillation.
MedLine Citation:
PMID:  19911873     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation is associated with a fivefold increased risk for stroke, mostly secondary to thromboembolic events. Anticoagulation with a vitamin K antagonist is the standard medical therapy for these patients but is difficult to maintain within the therapeutic range and requires frequent monitoring and dose adjustments. Approximately 90% of thromboembolism occurs in the left atrial appendage (LAA) in patients with nonvalvular atrial fibrillation. Occlusion of flow into the LAA may prevent thrombus formation in the appendage and, hence, reduction of stroke. Recently, several percutaneous transcatheter techniques of LAA exclusion using the Percutaneous Left Atrial Appendage Transcatheter Occlusion device, the WATCHMAN device, and AMPLATZER septal occluder and cardiac plug have been employed, with encouraging results. Occlusion of the LAA may be an alternative to vitamin K antagonist therapy for selected patients.
Bryan P Yan; Thomas J Kiernan; Ignacio Gonzales-Cruz; Yat-Yin Lam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of medical devices     Volume:  6     ISSN:  1745-2422     ISO Abbreviation:  Expert Rev Med Devices     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230445     Medline TA:  Expert Rev Med Devices     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-20     Citation Subset:  IM    
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong, China.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / instrumentation
Atrial Appendage / pathology,  surgery*
Atrial Fibrillation / complications,  surgery*,  therapy*
Catheter Ablation
Clinical Trials as Topic
Echocardiography / methods
Equipment Design
Equipment and Supplies
Heart Atria / pathology*
Prostheses and Implants
Risk Factors
Stroke / etiology,  prevention & control*,  surgery*
Thromboembolism / prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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