Document Detail

Left atrial appendage function in patients with different pacing modes.
MedLine Citation:
PMID:  10817851     Owner:  NLM     Status:  MEDLINE    
Many studies suggest that patients who receive a ventricular pacemaker have a higher incidence of systemic thromboembolism compared to patients receiving a physiological pacemaker. However, the exact mechanism regarding the etiology of thromboembolism remains unclear. We evaluated the left atrial appendage (LAA) functions, using multiplane transesophageal echocardiography (TEE), in patients with different pacing modes. In order to evaluate the ejection fraction (EF), peak emptying (V(E)) and filling (V(F)) flow velocities of the LAA by TEE, we studied 31 patients (mean age 63+/-18.5 years) who had been paced for 5.0+/-2.9 years. Patients with atrial fibrillation, left ventricular dysfunction and mitral valve disease were excluded. The pacing indications were complete atrioventricular block (AVB) in 19 patients (9 VVI, 10 VDD or DDD) and sick sinus syndrome (SSS) in 12 patients (5 VVI, 7 DDD). Mean EF, V(E) and V(F) of the LAA were significantly lower in all patients with ventricular pacing (25.5+/-15.6%, 30.4+/-15.6 cm/s and 29. 1+/-19.2 cm/s, respectively) compared to those with physiologic pacing (48.5+/-16.9%, 59.6+/-16.3 cm/s, 57.9+/-18.5 cm/s, respectively) (P<0.01 in all). When patients were further classified with respect to underlying heart disease whether they had SSS or AVB, all measurements of the LAA (EF, V(E) and V(F)) in both subgroup of patients with SSS and AVB were found significantly lower in those with ventricular pacing than in those with physiologic pacing (Tables 3 and 4). This decrease, especially in LAA flow, was much greater in those with SSS (Mean V(E) and V(F) <20 cm/s). In a patient paced with VVI for SSS, a thrombus was detected within the LAA cavity. In conclusion, these results suggest that the pacing modality appeared to influence the LAA functions in paced patients. Patients with asynchronous ventricular pacing modes had a significantly higher incidence of depressed LAA functions than did patients with physiological pacing, especially more marked in patients with sick sinus syndrome. This may be a factor responsible for increased risk of thrombus formation and thromboembolic events in this patient population.
F Ertaş; S Güleç; I Dinçer; C Erol; E Tutar; M Güldal; R Karaoğuz; D Oral
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  73     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Department of Cardiology, Medical School of Ankara University, Ankara, Turkey.
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MeSH Terms
Aged, 80 and over
Atrial Function, Left / physiology*
Blood Flow Velocity / physiology
Cardiac Pacing, Artificial / adverse effects,  methods*
Follow-Up Studies
Heart Block / therapy,  ultrasonography
Heart Rate
Middle Aged
Sick Sinus Syndrome / therapy,  ultrasonography
Stroke Volume / physiology
Thromboembolism / etiology,  ultrasonography

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