| Left atrial appendage function in patients with different pacing modes. | |
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MedLine Citation:
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PMID: 10817851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many studies suggest that patients who receive a ventricular pacemaker have a higher incidence of systemic thromboembolism compared to patients receiving a physiological pacemaker. However, the exact mechanism regarding the etiology of thromboembolism remains unclear. We evaluated the left atrial appendage (LAA) functions, using multiplane transesophageal echocardiography (TEE), in patients with different pacing modes. In order to evaluate the ejection fraction (EF), peak emptying (V(E)) and filling (V(F)) flow velocities of the LAA by TEE, we studied 31 patients (mean age 63+/-18.5 years) who had been paced for 5.0+/-2.9 years. Patients with atrial fibrillation, left ventricular dysfunction and mitral valve disease were excluded. The pacing indications were complete atrioventricular block (AVB) in 19 patients (9 VVI, 10 VDD or DDD) and sick sinus syndrome (SSS) in 12 patients (5 VVI, 7 DDD). Mean EF, V(E) and V(F) of the LAA were significantly lower in all patients with ventricular pacing (25.5+/-15.6%, 30.4+/-15.6 cm/s and 29. 1+/-19.2 cm/s, respectively) compared to those with physiologic pacing (48.5+/-16.9%, 59.6+/-16.3 cm/s, 57.9+/-18.5 cm/s, respectively) (P<0.01 in all). When patients were further classified with respect to underlying heart disease whether they had SSS or AVB, all measurements of the LAA (EF, V(E) and V(F)) in both subgroup of patients with SSS and AVB were found significantly lower in those with ventricular pacing than in those with physiologic pacing (Tables 3 and 4). This decrease, especially in LAA flow, was much greater in those with SSS (Mean V(E) and V(F) <20 cm/s). In a patient paced with VVI for SSS, a thrombus was detected within the LAA cavity. In conclusion, these results suggest that the pacing modality appeared to influence the LAA functions in paced patients. Patients with asynchronous ventricular pacing modes had a significantly higher incidence of depressed LAA functions than did patients with physiological pacing, especially more marked in patients with sick sinus syndrome. This may be a factor responsible for increased risk of thrombus formation and thromboembolic events in this patient population. |
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Authors:
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F Ertaş; S Güleç; I Dinçer; C Erol; E Tutar; M Güldal; R Karaoğuz; D Oral |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 73 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-07-18 Completed Date: 2000-07-18 Revised Date: 2006-07-12 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 135-41 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical School of Ankara University, Ankara, Turkey. ertasf@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrial Function, Left / physiology* Blood Flow Velocity / physiology Cardiac Pacing, Artificial / adverse effects, methods* Echocardiography Female Follow-Up Studies Heart Block / therapy, ultrasonography Heart Rate Humans Male Middle Aged Sick Sinus Syndrome / therapy, ultrasonography Stroke Volume / physiology Thromboembolism / etiology, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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