| Left atrial appendage closure with Amplatzer cardiac plug for stroke prevention in atrial fibrillation: Initial Asia-Pacific experience. | |
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MedLine Citation:
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PMID: 21542102 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Left atrial appendage (LAA) is the main source of left atrial thrombus that causes stroke in patients with non-valvular atrial fibrillation (NVAF). This study reported the initial safety, feasibility and 1-year clinical outcomes following AMPLATZER cardiac plug (ACP) implantation in Asia-Pacific region. METHODS: Twenty NVAF patients (16 males, age 68±9 years) with high risk for developing cardioembolic stroke (CHADS(2) score: 2.3±1.3) and contraindications to warfarin received ACP implants from June 2009 to May 2010. Patients received general anesthesia (n=9) or controlled propofol sedation (n=11) and the procedures were guided by fluoroscopy and transesophageal echocardiography (TEE). Clinical follow-up was arranged at 1 month and then every 3-month after implantation, whereas, a TEE was scheduled at 1 month upon completion of dual anti-platelet therapy. RESULTS: The LAA was successfully occluded in 19/20 patients (95%) at 2 Asian centers. One procedure was abandoned because of catheter-related thrombus formation. Other complications included coronary artery air embolism (n=1) and TEE-attributed esophageal injury (n=1). The median procedural and fluoroscopic times were 79 (IQR: 59-100) and 18 (IQR 12-27) minutes respectively. The mean size of implant was 23.6±3.1 mm. The average hospital stay was 1.8±1.1 days. Follow-up TEE showed all the LAA orifices were sealed without device-related thrombus formation. No stroke or death occurred at a mean follow-up of 12.7±3.1 months. CONCLUSIONS: Our preliminary data suggested LAA closure with ACP is safe, feasible with encouraging 1-year clinical outcomes. Further large-scaled trials are needed to confirm the efficacy of this device. © 2011 Wiley-Liss, Inc. |
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Authors:
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Yat-Yin Lam; Gabriel Wk Yip; Cheuk-Man Yu; Wilson Wm Chan; Boron Cw Cheng; Bryan P Yan; Richard Clugston; Gerald Yong; Tim Gattorna; Vincent Paul |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Division of Cardiology, SH Ho Cardiovascular and Stroke Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR. ylam@cuhk.edu.hk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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