Document Detail

Left atrial appendage clip occlusion: early clinical results.
MedLine Citation:
PMID:  19880144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Atrial fibrillation puts patients at significant risk for embolic stroke originating from the left atrial appendage. Few means are available for safe, effective, and durable left atrial appendage occlusion. A new clip device was evaluated with regard to safety and effectiveness for epicardial left atrial appendage occlusion. METHODS: Patients with atrial fibrillation undergoing elective cardiac surgery through a median sternotomy were enrolled for concomitant epicardial clip placement. Early postoperative and 3-month follow-up computed tomography studies were used to assess clip stability and left atrial appendage perfusion. RESULTS: From September 2007 to December 2008, 34 patients underwent successful clip placement. No device-related complications occurred. Operative mortality was 8.8% and not study or device related. Deployment was rapid, and left atrial appendage occlusion was confirmed by intraoperative transesophageal echocardiography in all patients. In addition to excellent clinical outcomes (no stroke/transient ischemic attack), serial computed tomography demonstrated stable clip location and appendage perfusion at 3 months in all patients. CONCLUSION: Safe, effective, and durable left atrial appendage occlusion can easily be achieved with this new clip. Further trials are necessary to evaluate the role of the left atrial appendage occlusion in stroke prevention.
Sacha P Salzberg; Andre Plass; Maximillian Y Emmert; Lotus Desbiolles; Hatem Alkadhi; Jurg Gr?nenfelder; Michele Genoni
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-01
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  139     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1269-74     Citation Subset:  AIM; IM    
Copyright Information:
2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland.
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MeSH Terms
Aged, 80 and over
Atrial Appendage / radiography,  surgery*,  ultrasonography
Atrial Fibrillation / complications,  diagnosis,  mortality,  surgery*
Cardiac Surgical Procedures / adverse effects,  instrumentation*,  mortality
Echocardiography, Transesophageal
Embolism / etiology,  prevention & control*
Equipment Design
Middle Aged
Pilot Projects
Risk Assessment
Risk Factors
Stroke / etiology,  prevention & control*
Surgical Instruments*
Time Factors
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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