| Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data from the LARGE Heart Study. | |
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MedLine Citation:
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PMID: 23307776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: - To use cardiovascular magnetic resonance to investigate left ventricular (LV) wall thickness and the presence of asymmetric hypertrophy in young army recruits before and after a period of intense exercise training. METHODS AND RESULTS: - Using cardiovascular magnetic resonance the left ventricular wall thickness was measured in all 17-segments and a normal range calculated for each. The prevalence of asymmetric wall thickening was assessed before and after training and defined by a ventricular wall thickness ≥13.0 mm that was >1.5-times the thickness of the opposing myocardial segment. Five-hundred-and-forty-one males (mean age 20 ± 2) were recruited, 309 underwent repeat scanning. Considerable variation in wall thickness was observed across the ventricle with progressive thickening on moving from the apex to base (p<0.001) and in the basal and mid-cavity septum compared to the lateral wall (11.0 ± 1.4 mm vs. 10.1 ± 1.3 mm; p<0.001). Twenty-three percent had a maximal wall thickness ≥13.0mm, whilst the prevalence of asymmetric wall thickening increased from 2.2% to 10% following the exercise-training program. In those who developed asymmetry the wall thickness to diastolic volume ration remained normal (0.09 ± 0.02 mm x m(2) x ml(-1)) indicative of a remodelling response to exercise. CONCLUSIONS: - In a cohort of healthy young Caucasian males we have demonstrated that wall thickness frequently measures ≥13.0 mm and that asymmetric wall thickening is common and can develop as part of the physiological response to exercise. A diagnosis of hypertrophic cardiomyopathy in young athletic males should therefore not be made purely on the basis of regional wall thickening. |
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Authors:
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Phong T Lee; Marc R Dweck; Sparsh Prasher; Anoop Sv Shah; Steve E Humphries; Dudley J Pennell; Hugh E Montgomery; John R Payne |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: - ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UNITED KINGDOM. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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