Document Detail

Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study.
MedLine Citation:
PMID:  23307776     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To use cardiovascular magnetic resonance to investigate left ventricular wall thickness and the presence of asymmetrical hypertrophy in young army recruits before and after a period of intense exercise training.
METHODS AND RESULTS: Using cardiovascular magnetic resonance, the left ventricular wall thickness was measured in all 17 segments and a normal range was calculated for each. The prevalence of asymmetrical wall thickening was assessed before and after training and defined by a ventricular wall thickness ≥13.0 mm that was >1.5× the thickness of the opposing myocardial segment. Five hundred forty-one men (mean age, 20±2 years) were recruited, 309 underwent repeat scanning. Considerable variation in wall thickness was observed across the ventricle with progressive thickening on moving from the apex to base (P<0.001) and in the basal and midcavity septum compared with the lateral wall (11.0±1.4 versus 10.1±1.3 mm; P<0.001). Twenty-three percent had a maximal wall thickness ≥13.0 mm, whereas the prevalence of asymmetrical wall thickening increased from 2.2% to 10% after the exercise-training program. In those who developed asymmetry, the wall thickness/diastolic volume ration remained normal (0.09±0.02 mm⋅m(2)⋅mL(-1)), indicative of a remodeling response to exercise.
CONCLUSIONS: In a cohort of healthy young white men, we have demonstrated that wall thickness frequently measures ≥13.0 mm and that asymmetrical wall thickening is common and can develop as part of the physiological response to exercise. A diagnosis of hypertrophic cardiomyopathy in young athletic men should, therefore, not be made purely on the basis of regional wall thickening.
Phong T Lee; Marc R Dweck; Sparsh Prasher; Anoop Shah; Steve E Humphries; Dudley J Pennell; Hugh E Montgomery; John R Payne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-10
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  6     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-05-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
Analysis of Variance
Cardiomegaly, Exercise-Induced*
Cardiomyopathy, Hypertrophic / diagnosis*,  ethnology,  pathology,  physiopathology
Diagnosis, Differential
European Continental Ancestry Group
Great Britain / epidemiology
Heart Ventricles / pathology*
Hypertrophy, Left Ventricular / diagnosis*,  ethnology,  pathology,  physiopathology
Magnetic Resonance Imaging
Military Personnel*
Observer Variation
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Young Adult
Grant Support
PG08/008//British Heart Foundation; RG/08/008/25291//British Heart Foundation
Comment In:
Circ Cardiovasc Imaging. 2013 Sep;6(5):e28   [PMID:  24046383 ]
Circ Cardiovasc Imaging. 2013 Sep;6(5):e29   [PMID:  24046384 ]

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