|Left ventricular systolic dyssynchrony in patients with isolated symptomatic myocardial bridge.|
|PMID: 23036109 Owner: NLM Status: MEDLINE|
|OBJECTIVES: The impact of myocardial bridge (MB) on left ventricular (LV) systolic synchrony is insufficiently understood.
DESIGN: Thirty-five subjects with isolated mid-left, anterior, descending artery (LAD) MB, preserved LV ejection fraction (LVEF > 50%), and otherwise, normal coronary angiogram were identified from 3607 patients who underwent diagnostic coronary angiography and were evaluated by tissue Doppler imaging and real-time three-dimensional echocardiography (RT3DE). Control subjects consisted of 26 age and sex-matched coronary angiographically "normal" subjects.
RESULTS: MB patients were characterized by reduced, early, diastolic strain rate in LAD-supplied apical segments (lateral and anterior), with prevalence of LV systolic dyssynchrony of 25.7% (9/35). MB patients were further classified by the medians of MB stenosis and length. For MB stenosis < 52.5%, Class I: length < 17 mm (n = 7), Class II: length ≥ 17 mm (n = 10); for stenosis ≥ 52.5%, Class III: length < 17 mm (n = 10), Class IV: length ≥ 17 mm (n = 8). Binary Logistic regression model revealed that higher MB lesion classification (odds ratio: 4.944, 95%CI 1.174-20.82, P < 0.05) and hypertension (odds ratio: 15.32, 95%CI: 1.252-187.6, P < 0.05) are statistically associated with LV systolic dyssynchrony, which was independent of LV mass.
CONCLUSIONS: MB in the mid LAD is associated with myocardial dyssynchrony. Hypertensive individuals and those with more severe bridging (determined by length and stenosis) tend to have an increased incidence of dyssynchrony.
|Wei Cai; Yan Dong; Xin Zhou; Shao-Bo Chen; Ji-Hong Zhao; Tie-Min Jiang; Yu-Ming Li|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-11-01|
|Title: Scandinavian cardiovascular journal. Supplement Volume: 47 ISSN: 1651-2510 ISO Abbreviation: Scand Cardiovasc J Suppl Publication Date: 2013 Feb|
|Created Date: 2013-01-17 Completed Date: 2013-07-02 Revised Date: 2013-08-14|
Medline Journal Info:
|Nlm Unique ID: 9711058 Medline TA: Scand Cardiovasc J Suppl Country: England|
|Languages: eng Pagination: 11-9 Citation Subset: IM|
|Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of Chinese People's Armed Police Forces, Tianjin, PR China.|
|APA/MLA Format Download EndNote Download BibTex|
Hypertension / complications
Myocardial Bridging / complications*, diagnosis
Predictive Value of Tests
Severity of Illness Index
Ventricular Dysfunction, Left / diagnosis, etiology*, physiopathology
Ventricular Function, Left*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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