Document Detail


Left ventricular systolic dyssynchrony in patients with isolated symptomatic myocardial bridge.
MedLine Citation:
PMID:  23036109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The impact of myocardial bridge (MB) on left ventricular (LV) systolic synchrony is insufficiently understood.
DESIGN: Thirty-five subjects with isolated mid-left, anterior, descending artery (LAD) MB, preserved LV ejection fraction (LVEF > 50%), and otherwise, normal coronary angiogram were identified from 3607 patients who underwent diagnostic coronary angiography and were evaluated by tissue Doppler imaging and real-time three-dimensional echocardiography (RT3DE). Control subjects consisted of 26 age and sex-matched coronary angiographically "normal" subjects.
RESULTS: MB patients were characterized by reduced, early, diastolic strain rate in LAD-supplied apical segments (lateral and anterior), with prevalence of LV systolic dyssynchrony of 25.7% (9/35). MB patients were further classified by the medians of MB stenosis and length. For MB stenosis < 52.5%, Class I: length < 17 mm (n = 7), Class II: length ≥ 17 mm (n = 10); for stenosis ≥ 52.5%, Class III: length < 17 mm (n = 10), Class IV: length ≥ 17 mm (n = 8). Binary Logistic regression model revealed that higher MB lesion classification (odds ratio: 4.944, 95%CI 1.174-20.82, P < 0.05) and hypertension (odds ratio: 15.32, 95%CI: 1.252-187.6, P < 0.05) are statistically associated with LV systolic dyssynchrony, which was independent of LV mass.
CONCLUSIONS: MB in the mid LAD is associated with myocardial dyssynchrony. Hypertensive individuals and those with more severe bridging (determined by length and stenosis) tend to have an increased incidence of dyssynchrony.
Authors:
Wei Cai; Yan Dong; Xin Zhou; Shao-Bo Chen; Ji-Hong Zhao; Tie-Min Jiang; Yu-Ming Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-01
Journal Detail:
Title:  Scandinavian cardiovascular journal. Supplement     Volume:  47     ISSN:  1651-2510     ISO Abbreviation:  Scand Cardiovasc J Suppl     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-07-02     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9711058     Medline TA:  Scand Cardiovasc J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
Affiliation:
Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of Chinese People's Armed Police Forces, Tianjin, PR China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Coronary Angiography
Cross-Sectional Studies
Diastole
Echocardiography, Doppler
Echocardiography, Three-Dimensional
Female
Humans
Hypertension / complications
Logistic Models
Male
Middle Aged
Multivariate Analysis
Myocardial Bridging / complications*,  diagnosis
Odds Ratio
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Stroke Volume
Systole
Ventricular Dysfunction, Left / diagnosis,  etiology*,  physiopathology
Ventricular Function, Left*

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