Document Detail

Left ventricular systolic dyssynchrony in patients with isolated symptomatic myocardial bridge.
MedLine Citation:
PMID:  23036109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The impact of myocardial bridge (MB) on left ventricular (LV) systolic synchrony is insufficiently understood.
DESIGN: Thirty-five subjects with isolated mid-left, anterior, descending artery (LAD) MB, preserved LV ejection fraction (LVEF > 50%), and otherwise, normal coronary angiogram were identified from 3607 patients who underwent diagnostic coronary angiography and were evaluated by tissue Doppler imaging and real-time three-dimensional echocardiography (RT3DE). Control subjects consisted of 26 age and sex-matched coronary angiographically "normal" subjects.
RESULTS: MB patients were characterized by reduced, early, diastolic strain rate in LAD-supplied apical segments (lateral and anterior), with prevalence of LV systolic dyssynchrony of 25.7% (9/35). MB patients were further classified by the medians of MB stenosis and length. For MB stenosis < 52.5%, Class I: length < 17 mm (n = 7), Class II: length ≥ 17 mm (n = 10); for stenosis ≥ 52.5%, Class III: length < 17 mm (n = 10), Class IV: length ≥ 17 mm (n = 8). Binary Logistic regression model revealed that higher MB lesion classification (odds ratio: 4.944, 95%CI 1.174-20.82, P < 0.05) and hypertension (odds ratio: 15.32, 95%CI: 1.252-187.6, P < 0.05) are statistically associated with LV systolic dyssynchrony, which was independent of LV mass.
CONCLUSIONS: MB in the mid LAD is associated with myocardial dyssynchrony. Hypertensive individuals and those with more severe bridging (determined by length and stenosis) tend to have an increased incidence of dyssynchrony.
Wei Cai; Yan Dong; Xin Zhou; Shao-Bo Chen; Ji-Hong Zhao; Tie-Min Jiang; Yu-Ming Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-01
Journal Detail:
Title:  Scandinavian cardiovascular journal. Supplement     Volume:  47     ISSN:  1651-2510     ISO Abbreviation:  Scand Cardiovasc J Suppl     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-07-02     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9711058     Medline TA:  Scand Cardiovasc J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of Chinese People's Armed Police Forces, Tianjin, PR China.
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MeSH Terms
Case-Control Studies
Coronary Angiography
Cross-Sectional Studies
Echocardiography, Doppler
Echocardiography, Three-Dimensional
Hypertension / complications
Logistic Models
Middle Aged
Multivariate Analysis
Myocardial Bridging / complications*,  diagnosis
Odds Ratio
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Stroke Volume
Ventricular Dysfunction, Left / diagnosis,  etiology*,  physiopathology
Ventricular Function, Left*

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