Document Detail

Left ventricular rupture due to HIV-associated T-cell lymphoma.
MedLine Citation:
PMID:  20844622     Owner:  NLM     Status:  MEDLINE    
Patients with lymphoma can develop cardiac involvement that includes malignant pericardial effusions and myocardial infiltration, but extensive myocardial invasion by tumor with resultant rupture has been reported only rarely. We report a case of a patient with human immunodeficiency virus and T-cell lymphoma who presented with signs and symptoms that were suggestive of a non-ST-elevation myocardial infarction. Plans were made for cardiac catheterization, but the patient developed thrombocytopenia after the initiation of heparin and eptifibatide. Cardiac catheterization was deferred, and shortly afterwards he had a witnessed cardiac arrest in the hospital and could not be resuscitated. Autopsy revealed transmural infiltration of the myocardium with lymphoma and resultant rupture of the left ventricular free wall. To our knowledge, this is the 1st reported case of left ventricular free-wall rupture due to transmural infiltration by human-immunodeficiency-virus-associated peripheral T-cell lymphoma.We conclude that noncoronary causes of chest pain, including direct myocardial infiltration, should be considered in immunocompromised patients with lymphoma.
Ehrin J Armstrong; Prashant Bhave; Dorothy Wong; Philip C Ursell; Lawrence Kaplan; Yerem Yeghiazarians; Weiyun Z Ai
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  37     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-13     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  457-60     Citation Subset:  IM    
Division of Cardiology, University of California, San Francisco 94143, California, USA.
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MeSH Terms
Chest Pain / etiology
Fatal Outcome
Heart Arrest / etiology
Heart Rupture / etiology*,  pathology
Heart Ventricles / pathology*
Lymphoma, AIDS-Related / complications*,  pathology
Lymphoma, T-Cell / complications*,  pathology
Middle Aged
Neoplasm Invasiveness

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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