Document Detail

Left ventricular noncompaction: a 25-year odyssey.
MedLine Citation:
PMID:  22284845     Owner:  NLM     Status:  MEDLINE    
Left ventricular noncompaction (LVNC) is a cardiomyopathy associated with sporadic or familial disease, the latter having an autosomal dominant mode of transmission. The clinical features associated with LVNC vary from asymptomatic to symptomatic patients, with the potential for heart failure, supraventricular and ventricular arrhythmias, thromboembolic events, and sudden cardiac death. Echocardiography is the diagnostic modality of choice, revealing the pathognomonic features of a thick, bilayered myocardium; prominent ventricular trabeculations; and deep intertrabecular recesses. Widespread use and advances in the technology of echocardiography and cardiac magnetic resonance imaging are increasing awareness of LVNC, and cardiac magnetic resonance imaging is improving the ability to stage the severity of the disease and potential for adverse clinical consequences. Study of LVNC through research in embryology, imaging, and genetics has allowed enormous strides in the understanding of this heterogeneous disease over the past 25 years.
Timothy E Paterick; Matt M Umland; M Fuad Jan; Khawaja Afzal Ammar; Christopher Kramer; Bijoy K Khandheria; James B Seward; A Jamil Tajik
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-01-27
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  25     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-07-24     Revised Date:  2012-08-22    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway #845, Milwaukee, WI 53215, USA.
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MeSH Terms
Cardiomyopathies / complications,  pathology*,  therapy,  ultrasonography
Diagnosis, Differential
Heart Ventricles / pathology*
Magnetic Resonance Imaging
Myocardium / pathology*
Comment In:
J Am Soc Echocardiogr. 2012 Jul;25(7):806   [PMID:  22658564 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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