Document Detail

Left Ventricular Mechanical Dyssynchrony Impairs Exercise Capacity in Patients With Coronary Artery Disease With Preserved Left Ventricular Systolic Function and a QRS Duration ≤120ms.
MedLine Citation:
PMID:  22240594     Owner:  NLM     Status:  Publisher    
Background: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs ≤8, which is the mean MET of the study population) were older (71±7 vs. 62±2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.
Mei Wang; Guo-Hui Yan; Wen-Sheng Yue; Chung-Wah Siu; Kai-Hang Yiu; Stephen W L Lee; Chu Pak Lau; Hung-Fat Tse
Related Documents :
22082574 - First clinical evaluation of a luminal self-expanding shield in patients with intermedi...
2049244 - Influence of ace inhibitors on free radicals and reperfusion injury: pharmacological cu...
15851624 - Quantitative coronary angiogram analysis: nifedipine retard versus angiotensin-converti...
21604104 - Early double stent thrombosis associated with clopidogrel hyporesponsivenesss.
3976474 - Nuclear magnetic resonance analysis of acute myocardial infarction in dogs: the effects...
16650244 - Intravascular ultrasound in patients with challenging in-stent restenosis: importance o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiology, Department of Medicine, Queen Mary Hospital.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Safety and tolerability of once-daily controlled-release carvedilol 10-80 mg in Japanese patients wi...
Next Document:  Tissue Doppler Imaging Dyssynchrony Parameter Derived From the Myocardial Active Wall Motion Improve...