Document Detail

Left Ventricular Mass and Function With Reduced-Fat or Reduced-Carbohydrate Hypocaloric Diets in Overweight and Obese Subjects.
MedLine Citation:
PMID:  22068866     Owner:  NLM     Status:  Publisher    
In animals, carbohydrate and fat composition during dietary interventions influenced cardiac metabolism, structure, and function. Because reduced-carbohydrate and reduced-fat hypocaloric diets are commonly used in the treatment of obesity, we investigated whether these interventions differentially affect left ventricular mass, cardiac function, and blood pressure. We randomized 170 overweight and obese subjects (body mass index, 32.9±4.4; range, 26.5-45.4 kg/m(2)) to 6-month hypocaloric diets with either reduced carbohydrate intake or reduced fat intake. We obtained cardiac MRI and ambulatory blood pressure recordings over 24 hours before and after 6 months. Ninety subjects completing the intervention period had a full cardiac MRI data set. Subjects lost 7.3±4.0 kg (7.9±3.8%) with reduced-carbohydrate diet and 6.2±4.2 kg (6.7±4.4%) with reduced-fat diet (P<0.001 within each group; P=not significant between interventions). Caloric restriction led to similar significant decreases in left ventricular mass with low-carbohydrate diets (5.4±5.4 g) or low-fat diets (5.2±4.8 g; P<0.001 within each group; P=not significant between interventions). Systolic and diastolic left ventricular function did not change with either diet. The 24-hour systolic blood pressure decreased similarly with both interventions. Body weight change (β=0.33; P=0.02) and percentage of ingested n-3 polyunsaturated fatty acids (β=-0.27; P=0.03) predicted changes in left ventricular mass. In conclusion, weight loss induced by reduced-fat diets or reduced-carbohydrate diets similarly improved left ventricular mass in overweight and obese subjects over a 6-month period. However, n-3 polyunsaturated fatty acid ingestion may have an independent beneficial effect on left ventricular mass.
Sven Haufe; Wolfgang Utz; Stefan Engeli; Petra Kast; Jana Böhnke; Martin Pofahl; Julius Traber; Verena Haas; Mario Hermsdorf; Anja Mähler; Andreas Busjahn; Susanne Wiesner; Christoph Otto; Heidrun Mehling; Friedrich C Luft; Michael Boschmann; Jeanette Schulz-Menger; Jens Jordan
Related Documents :
23762426 - Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
22068866 - Left ventricular mass and function with reduced-fat or reduced-carbohydrate hypocaloric...
10675246 - Prospective randomized trial of early initiation and hospital discharge on a liquid die...
8577016 - Structured triglycerides were well tolerated and induced increased whole body fat oxida...
10460206 - Liquid concentrates are lower in bioavailable tryptophan than powdered infant formulas,...
19366336 - Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-7
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, a joint cooperation between Charité University Medical Faculty and Max-Delbrück Center for Molecular Medicine, Berlin, Germany; Working Group Cardiac MR at the Experimental and Clinical Research Center, a joint cooperation between Charité University Medical Faculty Berlin and Max-Delbrück Center for Molecular Medicine, and HELIOS Klinikum Berlin-Buch, Department Cardiology and Nephrology, Berlin, Germany; Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany; Healthtwist GmbH, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relation between blood pressure and vascular events and mortality in patients with manifest vascular...
Next Document:  Carotid Stiffness in Young Adults: A Life-Course Analysis of its Early Determinants: The Amsterdam G...